Dementia à la Mold? Fungi May Lurk in Alzheimer’s Brains
Fungal cells cropped up in multiple brain regions of all AD brains examined, but how they got there and what they are doing remains mysterious.
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Do APP Knock-ins Call Overexpression Models of AD into Question?
P25 overexpression in APP transgenic mice is one of perhaps many artifacts of APP overexpression, APP, researchers charge. Do APP/PS1 transgenic mouse phenotypes need re-evaluation?
Robert D. Terry, 93, Co-Founder of U.S. Alzheimer’s Research
A veteran of the Battle of the Bulge, Terry trained legions of neuropathologists at Einstein and UCSD. He described paired helical filaments and linked synapse loss to cognitive decline.
Closing in on a Blood Test for Alzheimer’s?
A Japanese company enters the arena with a plasma Aβ test that rivals CSF for detecting brain amyloid.
Herpes Triggers Amyloid—Could This Virus Fuel Alzheimer’s?
Herpes viruses that are commonly found in human brain promote rapid Aβ fibrillization and deposition in AD model systems.
Topline Result for First DIAN-TU Clinical Trial: Negative on Primary
DIAN, Roche, Lilly disclose that neither gantenerumab nor solanezumab slowed cognitive decline in the first-pass comparison of drug and placebo groups. Analyses are ongoing; dose may have been too low.
Forget Typical Alzheimer's: AI Finds Four Types.
Machine learning analysis of 912 PET scans says neurofibrillary tangles spread through the AD brain in one of four distinct patterns.
Chris Dobson, Master of Protein Folding Research, Dies at 69
A chemist at the University of Cambridge, Dobson developed equations that described the kinetics of protein aggregation in diseases such as Alzheimer’s.
Could Contaminated Scalpels Seed Amyloidosis?
A panel of experts concludes the evidence for this scary prospect is weak, but recommends neurosurgeons use separate neurosurgical instruments for young and old patients. The experts called for further studies.
Lipid-Laden, Sluggish Microglia? Blame Aβ.
Droplets of triglycerides accumulate in microglia exposed to Aβ fibrils. These cells barely ate Aβ, and released molecules that damage neurons.
FDA Invites Comment on Drug Testing Guidance for Early AD
Scientists have turned their attention toward testing therapies in early-stage patients who have underlying brain pathology but little to no functional impairment...
Inventory of Tau Modifications Hints at Undiscovered Functions
A new mass spectrometry analysis provides the most thorough catalog yet of modifications to tau.
Peripheral Aβ Can Accumulate in Brain, Trigger Degeneration
Wild-type mice exposed to blood from Alzheimer’s amyloidosis mice developed plaques, tau phosphorylation, neuroinflammation, and synaptic deficits.
When Host Proteins Coat Virus, Amyloid Fibrils Form
Viral surfaces attract proteins from the extracellular environment of the person they infect. This corona of host proteins makes the virus more or less infective—and promotes amyloid fibrils.
Neuronal Exosomes Embroiled in Controversy
The L1CAM cell adhesion marker is a widely adopted marker of neuron-derived extracellular vesicles. Except it cannot be found in those teeny packets, claims a new study.
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