No Pony in There: Bapi Fails Mild to Moderate ApoE4 Carriers
Pfizer conceded that results of the first of four Phase 3 trials of intravenous bapineuzumab failed to meet its co-primary endpoints in patients with mild to moderate AD...
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Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
Rare mutations in a microglial receptor contribute as much to Alzheimer’s risk as does the more common ApoE4 genotype...
Does ApoE4 Lower Brain Metabolism Independently of Aβ?
Chalk another one up for the “not-all-about-amyloid” camp...
Escort Service: P-Glycoprotein Ushers Aβ from Brain
Keeping brain amyloid-β (Aβ) levels in check means controlling both the means of production and the method of disposal...
ABCA1 Loss Lowers ApoE, Not Amyloid; New ApoE Immunology
A foursome of papers on ApoE deserves attention this week. Having plenty of ApoE is a prerequisite for...
A Blood Test for AD?
Plasma cholesterol measurements have done wonders for cardiovascular disease management...
One Thumb Up on Dietary Fat, One Down on Vitamins, Two Down on Estrogen
A foursome of papers in the February 17 Archives of Neurology continues the shifting debates about three epidemiological questions in Alzheimer’s research...
Popcorn Plaque? Alzheimer Disease Is Slow, Yet Plaque Growth Is Fast
Thanks to a new imaging technology, researchers discovered that amyloid plaques can literally show up overnight and grow to their full size in just a few days...
Spine Shrinkers: Aβ Oligomers Caught in the Act
Though it’s now widely accepted that amyloid-β oligomers are bad news for dendritic spines, most of the data supporting this contention comes from cell culture or tissue slice experiments...
Multiple Hits Explain Selective Loss of Dopamine Neurons in PD
One of the enduring mysteries of Parkinson disease has been the exquisite specificity of neuronal death...
Special Delivery: NGF Trial Puts Growth Factor Where It’s Needed
The development of neurotrophic factors for treatment of Alzheimer disease (AD) and other neurodegenerative disorders has proceeded in fits and starts, in no small part due to...
Can Travel, Will Deposit: Aβ via the Perforant Pathway?
Two studies indicate that the amyloid deposits found in the hippocampus may come not so much from local cells but arrive via the axons of distant neurons projecting there...
Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
Clinical and genetic data have linked Parkinson’s and other synucleinopathies to Gaucher’s disease...
The Quality-of-Life Balance: Anticholinergics in the Hot Seat
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...
Perpetrator and Savior—Presenilins Cut Both Ways
Presenilins deliver the final cut to unleash the Aβ peptides that form the amyloid plaques that gum up the brains of Alzheimer disease patients...
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