Pittsburgh Compound-B Zooms into View
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
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No Toxicity in Tau’s Tangles?
In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might...
Statin Use and Alzheimer Disease: A Tale of Two Methodologies?
Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to...
Linking APP to Apoptosis—p53 Does the Trick
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
Microglia—Medics or Meddlers in Dementia
The first rule of triage is do no harm, but try telling that to microglia...
A Homeo Run for the Vascular Hypothesis?
The vascular hypothesis of Alzheimer disease suggests that pathology starts with hypoperfusion, or decreased blood flow to the brain...
What Do Clinicians Say? Peers Welcome Revised Criteria
A comprehensive proposal of new diagnostic criteria marked a highlight at the International Conference on Alzheimer’s Disease...
Honolulu: The Missing Link? Tau Mediates Aβ Toxicity at Synapse
For the first time, a paper details a molecular mechanism that links tau to Aβ toxicity at the synapse...
New Gene for ALS: RNA Regulation May Be Common Culprit
Scientists have uncovered a fresh clue in the mystery that is amyotrophic lateral sclerosis...
Smoking Debate Still Smolders
Everyone knows that smoking is bad for you. But there is some evidence, both epidemiological and molecular, that smokers are at reduced risk for neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD)...
Hyperactive Neurons and Amyloid, Side by Side
Experimental evidence and plain common sense tell us that neurons lose activity in Alzheimer disease...
Ironing out the Role of Metals in Neurodegenerative Diseases
A large, collaborative group led by Julie Andersen at the Buck Institute for Research in Aging, Novato, California, demonstrates that lowering the bioavailability of iron—both systemically and in dopaminergic neurons—protects mice against chemically induced Parkinson's...
Smuggling Antibodies to BACE Across the Blood-Brain Barrier
The tight barrier between brain and blood vessels guards the brain from harm, but also frustrates scientists trying to deliver therapeutic molecules to the CNS...
ApoE’s Secret Revealed? Protein Promotes Aβ Degradation
Despite its spot on top of the pile of genetic risk factors for late onset AD, ApoE has remained an enigma on the pathophysiological level...
Amyloid Oligomer Antibody—One Size Fits All?
Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ...
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