In New ALS/FTD Mouse Model, Poly(GR) Peptides Poison Ribosomes
Chronic inhibition of protein synthesis, and slowing the dispersal of stress granules, contribute to neurodegeneration in C9ORF72 ALS/FTD.
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Nilvadipine Fails to Slow Cognitive Decline in AD Patients
Believed to be an amyloid-lowering agent, the blood pressure drug did not help people at the dementia stage of disease.
Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
Sans Synuclein Tetramers, Mice Mimic Parkinson’s Disease
Mutations that destabilize α-synuclein tetramers leave young mice with severe and progressive motor problems resembling those of PD.
Could Rogue APP Variants Invade Genome of Individual Neurons?
In a new take on mosaicism and Alzheimer’s, scientists claim that APP mRNAs convert into DNA and reinsert into the genome. Full of mutations, these “genomic cDNAs” crop up in aging and sporadic AD.
First In Vivo Look at Amyloidosis Sparked by Dural Grafts
Researchers characterize widespread cerebral amyloid angiopathy and cortical plaques found in three living people who received dural grafts as children.
Could the Purported Muscle Exercise Hormone, Irisin, Jog Memory?
Levels of irisin are lower in brain and CSF of AD patients. Upping expression in mice protected them from synaptic deficits and memory problems.
An Antimicrobial Approach to Treating Alzheimer’s?
A periodontal pathogen found in human brains triggers AD pathology in mice. Will an antibiotic stave off dementia?
Clotting Protein from Blood Incites Microglia, and Synapses Die
When it seeps into the brain, fibrinogen activates innate immune responses that zap dendrites. And amyloid deposition has little to do with it.
Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease?
In several animal models, stimulating mitophagy lowered amyloid deposits and tau phosphorylation while improving learning and memory.
In Small Trial, EH301 Appears to Halt Progression of ALS
In a tiny pilot trial, people with amyotrophic lateral sclerosis who took a “cellular health and optimization” supplement were reported to have improved on several clinical outcome measures.
Do Tribes of Astrocytes Wage War on Synapses?
A newly uncovered population of astrocytes in layer V of the cortex modulate synapses by secreting a protein linked to Norrie disease, a form of blindness. Are other disease-related astroglia lurking in the brain?
AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy
The company halted its Phase 2 trial of ABBV-8E12 due to lack of efficacy.
Imaging Model Locates Epicenter of Disease, Predicts Atrophy
By analyzing a single MRI scan, researchers pinpointed the origin of frontotemporal dementia pathology and predicted its future progression.
Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance
DAPPD suppressed neuroinflammation and preserved cognition in mouse models of amyloidosis, suggesting potential for treating Alzheimer’s disease.
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