In Alzheimer Brain, Can Synaptic Pruning Be Good?
Provocative new data suggest that glial engulfment of synapses dampens network hyperexcitability early in disease. Key mediators: TREM2 and phosphatidylserine.
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Healthy CSF Teems with Diverse Lipoproteins
These greasy particles carry more than 300 different proteins. Some oil the immune response, inflammation, and wound healing.
Lipid-Laden, Sluggish Microglia? Blame Aβ.
Droplets of triglycerides accumulate in microglia exposed to Aβ fibrils. These cells barely ate Aβ, and released molecules that damage neurons.
In 3D Cell Model of AD, Microglia and CD8+ T Cells Gang Up on Neurons
Together, the two immune-cell types deal a neurodegenerative blow more powerful than either can inflict alone.
Alzheimer’s, Primary Age-Related Tauopathy Take Separate Paths
Compared to AD, tau tangles in PART accumulated slowly, and only in the medial temporal lobe. Cognition slipped subtly, and no amyloid amassed over three years.
Direct-to-Consumer Alzheimer’s Blood Test Opens Pandora’s Box
Experts say the low specificity of Quest Diagnostics’ plasma Aβ test could lead to more false than true positives, causing distress and confusion.
Proteins in Biofluids Foreshadow Dementia by 30 Years
Proteins involved in the extracellular matrix, metabolism, immunity, proteostasis, and synaptic function change in the CSF and plasma up to 30 years before dementia sets in.
At the Heart of Alzheimer’s in Down’s: Cerebrovascular Disease
Few people with Down's syndrome have cardiovascular risk factors, yet most develop cerebrovascular disease. Will this complicate anti-amyloid immunotherapy?
Goodbye, APOE4. Hello, Healthy Brain?
Two men with loss-of-function variants in their APOE4 alleles escaped amyloid pathology. One was in his 90s.
Meet the Switching Mice: They Flip Their Glia APOE4 to APOE2
Swapping allele expression in astrocytes lowered amyloid load, lessened gliosis, and improved memory. This works even after amyloidosis is in full swing.
Biomarkers and Efficacy: Not (Yet?) a Perfect Union
Scientists at AAIC debated discrepant results, updated a model of the biomarker-efficacy relationship, and debuted the CenTauR scale for tau PET.
What Factors Make Amyloid Immunotherapy Successful?
At AAIC 2023, scientists tied clinical success to drug exposure, speed of plaque clearance, amyloid negativity.
With Age, Microglia Pump cGAS, Revving Harmful Inflammation
DNA from leaky mitochondria unleash the cGAS-STING cascade, triggering interferon responses in the brain.
In Frontotemporal Lobar Dementia, TDP-43 Snaps into a Chevron Shape
A section of the protein folds on itself to form five layers. Three V-shaped layers cradle each other. This differs from the double-spiral fold in people with FTD/ALS.
Revised Again: Alzheimer's Diagnostic Criteria Get Another Makeover
The newly proposed scheme uses only amyloid and tau for diagnosis and staging. It establishes parallel tracks for fluid or imaging markers, and recognizes a clinical stage zero.
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