Does ApoE4 Risk Begin in the Womb?
Apolipoprotein E4 makes people prone to Alzheimer’s disease, but scientists don't know when that risk begins to manifest...
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No NOS Promotes Tau Pathology in APP Transgenic Mice
A new mouse model has achieved a long-sought pathological prize...
Gleevec for Alzheimer's?
Gleevec, the cancer "wonder drug" that has proven effective for gastrointestinal stromal tumors might also be useful for Alzheimer's patients, if only one could deliver it to the brain effectively...
New Orleans: Aβ Oligomers and Memory: Now They Are Good…
As evidence mounts against oligomers as culprits of Aβ neurotoxicity, their only defense hinges on the possibility that they may have some normal physiological function—even a slightly neurotrophic effect—on cognition which has yet to be characterized...
Follow the Leader to Higher BACE Levels
As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly...
Sharp Look at Complement in Genetics of Macular Degeneration
Last year, four independent research groups reported a linkage between polymorphisms in the complement factor H (CFH) gene to age-related macular degeneration...
A Tribute to Robert Katzman
Robert Katzman was a pioneer in bringing Alzheimer disease out of obscurity and into the forefront of medical, scientific, and social agenda of this country...
Brain Drain—“Glymphatic” Pathway Clears Aβ, Requires Water Channel
Researchers have shown that the CSF goes into the brain along very specific anatomical structures...
Gammagard™ Misses Endpoints in Phase 3 Trial
Topline data yesterday showed that intravenous immunoglobulin (IVIG) therapy, known as Gammagard™, failed to meet primary endpoints of slowing cognitive and functional decline...
TREM2 Mystery: Altered Microglia, No Effect on Plaques
In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
Antibodies Boost Microglial Appetite for Tau
Microglia internalize pathogenic forms of tau more robustly when anti-tau antibodies adorn the protein.
Partners in Crime: APP Fragment and Endosomal Protein Impair Endocytosis
A C-terminal fragment of APP recruits the protein APPL1 to endosomes, causing the enlarged, overactive vesicles seen early in Alzheimer’s disease.
Neither Exercise Nor Supplements Boost Cognition in Two Large Studies
In two trials, moderate exercise or supplements of omega-3 fatty acids and antioxidants failed to alter the course of cognitive decline in older adults.
In APP Knock-Ins, Calcium Chaos Dismantles Mushroom Spines
Excess Aβ42 trips up calcium homeostasis and precipitates the loss of spines thought to be important for memory.
Game Over? Federal Trade Commission Calls Brain-Training Claims Inflated
The FTC imposed a $2 million fine on Lumos Labs for overstating the benefits of the company’s Lumosity brain-training software.
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