Proteomics Highlight Alzheimer’s Changes in Matrisome, MAPK Signaling
Protein networks unseen in RNA data correlated closely with plaques, tangles, cognitive decline. Many are in the extracellular matrix.
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CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers
A curated panel of 48 proteins foretold cognitive decline. It also illuminated biological pathways involved in Alzheimer's disease.
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Nixing an endosomal targeting sequence shields APP from BACE1, reducing Aβ and pathologic C-terminal fragments in mice.
C1q from Microglia Meddles in Neuronal Translation
In mice, the innate immune protein slips into neurons, where it interacts with the translation machinery.
Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
Plaques comprise different-sized fibrils and cell membrane components, while tangles have distinct fibril structures segregated into intra- and extracellular compartments.
Part with PILRA, Power Up Microglia?
Knocking out this immunoglobulin receptor makes microglia fit to fight. An anti-PILRA antibody does the same.
Nix Tryptophan Metabolite, Temper Alzheimer’s?
Kynurenine curbs lactate production in astrocytes, which then fail to nourish neurons. Shutting down kynurenine production rescued cognition in AD mouse models.
Astrocytes Mount Complex Responses to AD. They Change Over Time
Single-nuclei RNA-Seq of 600,000 astrocytes defined seven subtypes. One revs up metabolic support late in Alzheimer’s disease, before flagging at its end stage.
Pertussis Toxin Stokes Autoimmune Reaction in Aβ-Vaccinated Mice
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
Dopamine Renders α-Synuclein Toxic to Neurons
In tomorrow's Nature Medicine, Bruce Yankner at Children's Hospital in Boston offers up a partial explanation for one of the abiding questions in Parkinson's research: Why do neurons die in such a selective pattern?...
Aiding and Abetting, Hyperactive CDK5 Gives Mouse Tangles
Despite its long and distinguished history in Alzheimer’s research, the microtubule-stabilizing protein tau still poses many a riddle to scientists. They do know that excessive phosphorylation of tau somehow figures in neurodegeneration...
Early Clinical Results of Cox 2 Inhibitor: No Pain, No Gain?
randomized trial to test the feasibility of using the COX-2 inhibitor nimesulide as a chronic treatment in Alzheimer's patients...
Presenilins Work Overtime to Control Akt, Tau, and Aβ—n-3 Fatty Acids Aid and Abet
The job description of presenilins (PS) in the business of neuron health and disease may be getting more complicated...
Aβ Assault on Neurons Targets ER, Calcium
When it works properly, the endoplasmic reticulum (ER) constantly pumps out newly synthesized membrane proteins, perfectly folded and sorted to their proper cellular destination...
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