Molecular Economics of AD—Supply, Demand, and the Aβ Glut
With the exception of familial cases, which can be traced to specific mutations, it is unclear why there’s a glut of...
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It’s a RAP—Loss of LRP Increases Amyloid Deposition in Mice
The low-density lipoprotein receptor-related protein, or LRP for short, is part of a family of receptors that mediate the uptake and destruction of extracellular molecules including apolipoprotein E. Previous in vitro experiments have shown...
Neuroprotection from Testosterone? (And a Link Between Hysterectomy and Parkinson's)
Two very different reports suggest that testosterone may be important in protecting neurons from Aβ, the peptide suspected of killing neurons in Alzheimer's disease...
Add Mental Exercise to Potential AD Protection
Evidence is accumulating that certain activities are correlated with a reduced risk of Alzheimer's disease, though whether this relationship is one of cause and effect is still open to debate. Recent articles have demonstrated this link...
The Unkindest Cut: Caspase-6 Cleavage of Huntingtin Produces Killer Fragment
Expansion of the polyglutamine (polyQ) tract in the huntingtin protein is necessary to cause Huntington disease, but it is not...
Inclusions: Part of the Problem, or the Solution?
The appearance of clots of abnormal proteins inside neurons is characteristic of...
SfN: Early Steps toward Parkinson Disease Blood Test
Biomarkers are the buzz of the field these days, and the hum was heard inside the beltway at the 35th Annual Conference of the Society for Neuroscience...
Tracing Alzheimer Disease Back to Source
The devastation that occurs by late-stage Alzheimer disease (AD) is well documented—almost every area of the...
Early Intervention Reverses Prion Disease
The neurological damage that comes with mad cow disease or other prion disorders could be reversible if...
Cold Spring Harbor: A Grab Bag from the Drug Discovery Folks
Drug discovery for neurodegenerative diseases continues on all fronts, from...
Aβ—Three Places, Three Ways of Wreaking Havoc
A riddle wrapped in a mystery inside an enigma. The phrase could just as easily apply to...
Calling for Backup: Microglia from Bone Marrow Fight Plaques in AD Mice
Do microglia promote the development of Alzheimer disease (AD) or hinder it?...
The Well-Tempered Immune System: Taming Microglia to Fight AD
Out-of-control T cells are blamed for the encephalitis that doomed Elan’s Aβ vaccine trial for Alzheimer disease (AD), and so researchers have turned their efforts toward...
Salzburg: New Proteins Redefine Frontotemporal Dementias
This is Part 1 of a two-part meeting story.
New Insights into Fibril Formation
Two papers in PNAS add to the growing body of work aimed at understanding the molecular interactions involved in the formation of amyloid fibrils...
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