Immunotherapy Interrupted—Inflammation by Interferon
Could interferon-γ (IFN-γ) be to blame for the encephalitis that brought an end to clinical trials of Elan’s amyloid-β (Aβ) vaccine?...
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Mapping Protein Networks in the Roundworm
Genome, transcriptome, proteome, and now we have the interactome, the full complement of protein-protein interactions that can occur in the cell...
Nitric Oxide and Zinc—Conspirators in Cell Death
Who would have thought that nitric oxide (NO) and zinc (Zn+) act in concert to activate apoptosis? That's the conclusion Stuart Lipton and colleagues propose in a report in the February 5 Neuron...
Friend or Foe? Tumor Suppressor p53 Enhances Huntingtin Toxicity
The tumor suppressor p53 is perhaps best known as a cellular watchdog that prevents cancer by...
p53 as Mediator of Oxidative Stress and Inflammation?
The tumor suppressor p53 appears to play a role in the pathogenesis of rheumatoid arthritis. What about Alzheimer's disease?
Madrid: ICAD Conference Draws to a Close
The 10th International Conference on Alzheimer’s Disease and Related Disorders, ICAD for short, ended yesterday just outside the palatial capital of Spain...
Salubrinal to the Rescue? New Compound Fights ER Stress
Researchers at Harvard Medical School report that they have identified a small molecule that interferes with a protein phosphatase in such a way that...
Madrid: News from the Vaccine Front—Bloody Complicated?
This concludes our 3-part series.
A Matter of Life and DAF: Pathways to Longevity Revealed in C. Elegans
In worms, the fountain of youth is not some magical elixir, but instead springs from...
The Long and Short of It: Insulin Trumps Telomeres in Organismal Aging
The progressive shortening of telomeres, those DNA caps that protect the ends of chromosomes, limits the lifespan of...
Synuclein and Parkinson's—It's All in the Dose
A paper in last Friday's Science reports that autosomal-dominant Parkinson's disease can be caused not only by α-synuclein mutations, but also by a triplication of a fragment of DNA containing the gene. This result suggests that dosage of α-synuclein...
San Diego: HLA and γ-Secretase? A Curiosity Now, But Just You Wait…
Venturing off the beaten path, <strong>Bryce Carey</strong> yesterday presented a poster at the Society for Neuroscience meeting about the interaction...
PARK8 is Cloned: Introducing…"Dardarin"
Biochemists, cell and molecular biologists, start your engines! You now have another Parkinson protein challenge...
Madrid: Pooled Antibody Cocktail, New Metal Quencher
This is Part 2 of a three-part report. See also <a href="/news/conference-coverage/madrid-clinical-trials-update-where-do-things-stand">Intro/Part 1</a> and <a href="/news/conference-coverage/madrid-highs-and-lows-insulin-connection">Part 3</a> of this clinical trials update.
Tangles, Neurodegeneration, Plaques—p25 Does it All
What, exactly, is the trigger for Alzheimer’s disease? Is there one such thing? At today’s annual meeting of the American Society for Biochemistry and Molecular Biology...
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