When Autophagy Stops, Microglia Sour into Senescence
Backed up, the cells never transitioned into a disease-associated state, shirking their plaque compaction and synapse protection duties.
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Adieu to Aduhelm: Biogen Stops Marketing Antibody
The company announced it would halt its post-market trial and stop selling the drug; the rights to it now revert to Swiss company Neurimmune.
Axons or Bust: To Reach Neuron Extremities, RNAs Hitch a Ride on Lysosomes
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
Does a Rare Fibronectin Variant Protect Against APOE4?
APOE4 carriers who also have a glycine-to-glutamic-acid substitution in the extracellular matrix protein were much less likely to develop Alzheimer’s disease.
In ADAD, Plaque Removal Improves Synaptic and Inflammatory Biomarkers
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid markers toward normal.
Could Bigger, More Complex Brains Explain Decreasing Dementia Incidence?
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.
Sans Plexin-B1, Glial Net Tightens Around Plaques
The astrocytic receptor enforces distancing among glial cells. Free from this constraint, they better contain plaques.
Unanimous: FDA Advisory Committee Backs Donanemab
All 11 committee members voted that the antibody was effective for people with MCI or mild AD dementia, with its benefits outweighing risks.
Remember Amyloid-eta? A Decade Later, News on a Physiological Function
To modulate synapses, Aη weakens ion flux through glutamate receptors and strengthens their non-ionotropic signaling. This dual action is a first, say scientists.
Not Just Alzheimer's: Microglia Sculpt the Brain in Health and Disease
These changeable cells can revive plasticity in the adult brain, match themselves to GABA synapses, and strip away healthy synaptic spines in reaction to stress. What do they do in depression, PTSD?
Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy
The largest autopsy-confirmed study of tau PET to date finds that the scans cannot identify early Alzheimer’s disease or PART.
Mark Your Calendars: Powerful CNN Documentary on Alzheimer’s
Invite your friends over, gather loved ones, serve some munchies, and settle in for a night of TV well worth watching...
Could “Big Tau” Protect Brain Regions from Tangles?
This super-sized isoform resists phosphorylation and aggregation, and occurs in cerebellum and brainstem, regions largely spared from tau pathology.
Put a RING on It: Targeting Intracellular Tau Aggregates for Destruction
A new strategy, which marries nanobodies or misfolded tau to a ubiquitin ligase RING domain, tags tangles for disposal.
RNA-Seq from 2.8 Million Cells Yields New Clues About Alzheimer's
Analysis identified neuronal populations that die early in AD and glial subtypes that expand. Gliosis signaled fast memory decline.
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