Donanemab Approval Likely to Pose New Quandaries for Clinicians
With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
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With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
At high concentrations, Aβ42 gums up the protease’s active site. A new theory explains how γ-secretase modulators work. One is en route to Phase 2.
Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
Early in the course of Alzheimer disease, blockages in axonal traffic lead to sick axons swollen with the jumbled pile-up of traffic components. The blockages precede...
Researchers from Spain describe changes in cannabinoid receptors in the brains of AD patients, as well as...
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today...
There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease...
Two papers in the 19 July Lancet bring both dismay and hope to the ongoing quest for more effective AD treatments...
Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball...
The 5th Clinical Trials in Alzheimer’s Disease conference offered new data from ongoing analyses of the Phase 3 programs on solanezumab and bapineuzumab...
Is the glass half empty or half full? Alzheimer disease clinicians might be asking themselves that question after seeing the long-awaited results of...
An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can...
This week's PNAS early online edition reports that, depending on the diet, even minor amounts of copper can lead to both amyloid plaques and a memory deficit in rabbits...
Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex...