Neurological Disease Institute Launched at UCSF
A research center focusing on advancing scientific understanding of brain disorders such as Alzheimer's disease, HIV dementia and stroke, was inaugurated earlier this month at UCSF...
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Nature Online
The British science journal Nature announced that it is becoming a "full-fledged" electronic journal beginning with this week's issue (at <a href="http://www.nature.com">http://www.nature.com</a>)...
Casting Doubt on Role of Oxidative Damage in ALS
Mutations in the enzyme for superoxide dismutase (SOD1) have been linked to 15 tp 20 percent of cases of amyotrophic lateral sclerosis (ALS), leading to a theory that the disease results when the defective enzyme allows super oxide radicals to build up...
PAK-3 Implicated in Mental Retardation
A mutation in the gene for PAK-3, a molecule that is thought to play a variety of roles in the nervous system, has been implicated in a form of X-chromosome-linked mental retardation...
CPG15: An Activity-dependent Neuronal Growth Promoter
Neuronal growth and synapse formation is regulated by a combination of activity-independent and activity-dependent mechanisms. In today's Science, E. Nedivi et al. describe CPG15, a molecule that enhances dendritic arbor growth...
Mitochondria Key to Glutamate Toxicity
Glutamate is a neurotransmitter that is toxic when too much of it is released by excessive neuronal activity or by brain injury. Some researchers have also proposed that glutamate toxicity drives the neurodegeneration...
How NF-κB Derails Apoptosis
A study published in tomorrow's Science provides new details of how the transcription factor NF-κB protects cells from apoptosis. C.-Y. Wang and colleagues report they have identified four genes that are targets of NF-κB activity...
Dopamine Transporter Imaging
A novel brain-imaging agent that binds selectively to dopamine transporter molecules promises to open up a window on the functioning of the brain's dopamine system. Dopamine is one of the brain's major neurotransmitters...
Potential NGF Drug-Delivery System
Puny polymer pellets show promise as a vehicle for delivering nerve-growth factor (NGF) to the basal forebrain, where the substance could rescue or even regenerate neurons damaged by Alzheimer's disease...
Gene Locus Found for Schizophrenia Risk
A 15-year study involving more than 100 families and 1,000 individuals has provided the first strong evidence of genetic susceptiblity to schizophrenia, within a stretch of chormosome 13...
Yin and Yang of Nerve Cell Growth
The growing tips, or growth cones, of neurons are confronted with a chemical cacophany of growth-guiding cues. How do they know which ones to heed?...
Epilepsy Drugs Effective for Agitation in AD
For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequently exhibit...
Stress Hormones Impair Recollection
Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories...
Membrane Rafts Revealed
It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs)...
Resisting Apoptosis
Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis...
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