TREM2 Protects the Brain From Herpes. The Virus Fights Back.
The microglial receptor activates an antiviral signaling cascade. The virus downregulates TREM2 expression after infecting microglia.
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The microglial receptor activates an antiviral signaling cascade. The virus downregulates TREM2 expression after infecting microglia.
In a head-to-head comparison, donanemab banished four times as much plaque in the first six months as aducanumab did, partly due to its faster titration.
Clusterin latches onto dimers of CD33 on the microglial cell surface, setting off inhibitory signaling that squelched phagocytosis.
At AD/PD, scientists placed more AD genes into microglial pathways, homed in on how TREM2 gets cleaved, debuted TREM2 agonists, and unearthed potential biomarkers.
The antisense oligonucleotide targets extremely rare variants of the superoxide dismutase 1 gene.
Safety and cerebrospinal fluid tau data from the six-month Phase 1 trial are now published.
Scientists showed how pooling microglia from different donors, then putting them through cutting-edge analyses, can link genetic variation to functional change.
Pumping Up Progranulin: Scientists Show New Efforts to Get it Done First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart Macrophages Blamed for Vascular Trouble in ApoE4 Carriers
While memory problems plague some people with lingering COVID symptoms, researchers do not yet understand what is going wrong in their brains.
Data from TRIAD cohort cast activated microglia, egged on by ApoE4, as harbingers of tau pathology and neurodegeneration. Data from BioFinder hint that other microglia restrain these processes.
One study links early menopause to tangles in early AD, another finds a sex difference in the brain's stress response. Could hormones fuel women’s higher risk of dementia?
The public database includes information about the structure, polarity, and stability of both pathogenic and functional amyloid folds.
Scientists devised fresh approaches for curbing tau tangles that might better reach the protein inside cells, or target several pathologies at once.
The D2 dopamine receptor agonist reduced agitation behaviors in Phase 3 trials of dementia due to AD.
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.