Non-Aβ, Non-Tau Drugs Tweak Markers, Cognition in Alzheimer’s, Huntington’s
Researchers at the online AAT-AD/PD meeting touted therapies that target neuroinflammation, synapses, epigenetic regulation, or the cortisol stress response.
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The Rain in Spain: Move Over Higgins, AI Spots Speech Patterns
AI-powered apps catch changes in how a person speaks that may reveal cognitive decline in frontotemporal dementia and early Alzheimer’s. Can smartphones deliver biomarkers for trial enrollment and diagnosis?
Vienna: New Tack to See Amyloid Oligomers in Body Fluids
The ICAD featured that the interest in small Aβ aggregates has branched out far beyond the initial debates about whether they even exist and which forms are important...
Automated CSF Tests: Check. Blood Tests: In the Works
Clinical validation is showing automated Elecsys, Lumipulse assays to be reliable and predictive. The story on blood tests has turned from non-starter to intensely promising for broad-based screening.
Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?
Large IDEAS data set establishes that PET scans are valuable in clinical practice. Other studies suggest CSF biomarker ratios perform nearly as well.
AD GWAS in African Americans Confirms, Reshuffles AlzGene List
African Americans carrying a variant in a cholesterol-processing gene have double the risk for Alzheimer’s than non-carriers...
Geneticists Seek Out Rare Contributors to Alzheimer’s
New genes linked to early and late-onset AD offer up mechanistic insight, potential targets for treatment.
At AAN, Sights Set on Antisense Therapies for Diseases of the Brain
Antisense oligonucleotides are raising hopes for tackling a wide range of brain disorders—is the enthusiasm warranted?
AFTD Holloway Summit 2022: Digital Assessment Tools for FTD
Digital Biomarkers of FTD: How to Move from Tech Tinkering to Trials? Digital Tools Abound, Yet Remote Biomarkers for FTD Remain Exploratory Changes in activity, speech, sleep, or the way a person moves are all examples of measurements that can be capture
SfN: Glial-Neuronal Signaling and AD Pathology
The interplay between glia and Aβ is one aspect of AD pathology that continues to mystify...
Astrocyte-to-Neuron Conversion Questioned
A spate of recent studies could not replicate the finding that knocking down the RNA-binding protein PTBP1 in astrocytes triggers their conversion to neurons. Leaky expression of the knockdown construct in endogenous neurons may be to blame.
Destined to Decline: Plaque-Tangle Combo Foretells Impairment
Cognitively normal people whose PET scans showed both plaques and tangles slid toward MCI or dementia within a few years. This risk was 19 times higher than in people without these deposits.
With Aduhelm in Retrenchment, Lecanemab Completes FDA Submission
In wake of Medicare coverage decision, Biogen jettisons aducanumab sales staff but keeps trials going. Eisai/Biogen wrap up accelerated approval application to U.S. regulators.
CAPturing Oligomers from Biofluids
With its affinity for β-sheets, a probe called Capture Molecule for Amyloid Precipitation, aka CAP-1, pulls α-synuclein and other soluble amyloids out of solution.
Behold, Plaques Mapped in Whole Brain at High Resolution
Advances in microscopy yield unprecedented views of Aβ plaques in vivo and ex vivo. The vistas offer new insights about how plaques form, grow, and clear.
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