Does Sleep Really Speed Clearance from the Brain?
A new study challenges this idea, finding that in mice, clearance of an injected dye slowed during sleep and anesthesia.
6473 RESULTS
Sort By:
A new study challenges this idea, finding that in mice, clearance of an injected dye slowed during sleep and anesthesia.
When carrying a pathogenic tau variant, microglia were bad at phagocytosis, barely made TREM2, and spat out neurotoxic proteins.
Aβ oligomers rev up glutamate release, depressing synapses for the long term. This instigates the pathological phosphorylation of tau.
Cerebrospinal fluid rides the pulses of cerebral arteries to enter the brain and spread into cortical tissue. This supports the existence of a human glymphatic system.
The enzyme cleaves off three amino acids at a time with a twist of the substrate, and a helping hand from a β-strand.
The FDA turned down Eli Lilly’s application based on insufficient safety data, with fewer than 100 people on the drug for one year.
Mice missing microglia develop astrogliosis and neurodegeneration by middle age. Giving them healthy microglia prevents or reverses pathology.
A panel of eight plasma proteins identified people who were on the path to Parkinson’s. Could this help select participants for prevention trials?
New candidate OXD-2314 binds 3R and 4R forms of tau and has begun Phase 1. The pan-tau tracer APN-1607 begins Phase 3 for progressive supranuclear palsy, a 4R tauopathy.
Preventing these peripheral phagocytes from creeping into the brain improves memory and ameliorates pathology in mouse models of Alzheimer’s.
These cells accumulate in old mouse and human hippocampi, as well as in a mouse model of neurodegenerative disease.
Quantifying 95 post-translational modifications of tau extracted from AD and control brains, a proteomics study proposes a “processive” model of phosphorylation, ubiquitination, acetylation that drive aggregation and map to distinct stages of disease.
Passive antibody immunization against prion protein prevents the spread of clinical disease to the brain of mice, even though the antibody works primarily by reducing prion replication in peripheral tissues, including the spleen. This is the astonishing news in a report in today’s Nature...
As a number of drug candidates to prevent, slow, or even halt Alzheimer's disease are being developed, a new urgency is driving efforts to develop tests that can diagnose the disease in its earliest stages...
Originally, vaccination with amyloid-β (Aβ) peptides aimed to fight Alzheimer disease by...