Lifestyle Interventions May Fend Off Decline; Social Contact Helps
In “Maintain Your Brain,” virtual interventions gave participants a memory boost. In EXERT, cognition held steady in people who exercised. Both groups were coached.
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In “Maintain Your Brain,” virtual interventions gave participants a memory boost. In EXERT, cognition held steady in people who exercised. Both groups were coached.
Scientists are refining safety and biomarker disclosure protocols, and are preparing to collect data on how well the new drugs work.
A mathematical model predicts that a tiny difference in CDR-SB after two years of treatment would grow fivefold over the next three years as progression curves separate.
Rare AD risk variants cluster within TREM2, SORL1, and the newcomer EXOC3L4. Rare mutations in ABCA7 associate with cerebral amyloid angiopathy.
Certain blood biomarker tests can tell that amyloid has built up in a person's brain and that their thinking will decline. What are the challenges ahead before these tests can be rolled out to medical care settings everywhere?
A cast of blood biomarkers for Alzheimer's has emerged from studies in research cohorts, and is now being put to the test in community cohorts. At AAIC, direct comparisons of top contenders showed that some detect amyloid and impending cognitive decline.
Finally, blood biomarkers for AD are here. Alas, the path to routine use is fraught. At AAIC, scientists discussed new guidelines, head-to-head comparisons, and logistical, technical, and ethical hurdles ahead.
New technology identified a rare population of astrocytes around blood vessels and hundreds of plaque-associated genes.
At AAIC, and a separate BACE symposium, scientists argued the case for resuming evaluation of these drugs in clinical trials.
Stalwart of dementia neuropathology was best known for his work on tau pathology.
Crenezumab Secondaries Negative; Gantenerumab OLE Hints at Efficacy Can BACE Inhibitors Stage a Comeback? High-Res Spatial Transcriptomics Offers New Views of Mouse Brain Alzheimer's Blood Tests Have Arrived; Road to Broad Use Still Stretches On Bloo
At AAIC, secondary endpoint data from the API Colombian study showed trends favoring crenezumab, while people taking gantenerumab in open-label extensions declined more slowly than matched controls.
In old mice, and young mice with amyloid, astrocytes in the hippocampus swell with autophagosomes, which sequester protein and derail cell functions.
With too few endothelial cells and too many fibroblasts in frontotemporal dementia due to insufficient progranulin, the blood-brain barrier and angiogenesis go haywire.
Correlating PET imaging with spatial transcriptomics revealed paths for the progression of tau pathology throughout the brain.