Head-to-Head Study Confirms Plasma p-Tau231 Rises First in Early AD
Plasma p-tau217 and p-tau181 better track amyloid PET, tangles, and subtle cognitive decline.
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Plasma p-tau217 and p-tau181 better track amyloid PET, tangles, and subtle cognitive decline.
A protective variant promotes anti-inflammatory microglia, while a risk variant depletes them.
In cognitively unimpaired older adults, some gut bacteria correlated with plaques and tangles, but not neurodegeneration.
In the Finnish city of Kuopio, surgeons and scientists have built a unique protocol. It improves life for people with hydrocephalus—and it banks cortical tissue rife with preclinical pathology and gene variants for Alzheimer's research.
Proteins involved in the extracellular matrix, metabolism, immunity, proteostasis, and synaptic function change in the CSF and plasma up to 30 years before dementia sets in.
For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus...
Scientists report that when the TREM2 fragment binds transgelin-2, it weakens phosphorylation of tau in neurons.
At the Keystone symposium on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session...
Protein networks unseen in RNA data correlated closely with plaques, tangles, cognitive decline. Many are in the extracellular matrix.
A curated panel of 48 proteins foretold cognitive decline. It also illuminated biological pathways involved in Alzheimer's disease.
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
Nixing an endosomal targeting sequence shields APP from BACE1, reducing Aβ and pathologic C-terminal fragments in mice.
In mice, the innate immune protein slips into neurons, where it interacts with the translation machinery.
Plaques comprise different-sized fibrils and cell membrane components, while tangles have distinct fibril structures segregated into intra- and extracellular compartments.
Knocking out this immunoglobulin receptor makes microglia fit to fight. An anti-PILRA antibody does the same.