Data Fabrication Ousted NIA Neuroscience Director Eliezer Masliah
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face allegations.
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Large Neuropathology GWAS Finds Four New Dementia Genes
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
Repeat Expansion Mutations More Common Than Thought
A whole-genome sequencing study estimated that people are two to three times more likely to be affected by these mutations than predicted by epidemiology.
Do Overloaded Microglia Smother Stressed Neurons?
In mice with prion disease, microglia shifted from gobbling up misfolded protein to engulfing flagging neurons. This change coincided with symptom onset.
Tweaked, Aβ-Antibodies Cross Blood Brain 'Border' (Bye Bye, Barrier?)
Scientists are honing transferrin receptors to whisk bulky, anti-Aβ antibodies throughout the brain without setting off ARIA and anemia. By halving the effector function of their antibody transport vehicle, Denali researchers blunted red blood cell loss a
Reconceptualizing the BBB: Is It Time to Swap ‘Barrier’ for ‘Border'?
The adaptive nature of the interface between blood and brain led some scientists to envision it more like an actively managed border crossing, not a wall.
Tweaked, Aβ-Antibodies Cross Blood-Brain ‘Border’ (Bye-Bye, Barrier?)
With genetic tinkering to their antibody transport vehicle, Denali scientists aim to temper both ARIA and anemia, while maintaining potency against Aβ.
Human Evolution Offers Clues to Frontotemporal Dementia
Brain regions that have most recently evolved may be most vulnerable to FTLD.
Chimeric Protein Dephosphorylates Tau, Improves Memory
In tauopathy mice, a peptide construct recruited protein phosphatase 1 to tau. Dephosphorylation lowered total tau, restoring synaptic density and memory.
Single-Cell Methylomes Offer Clues to Aging
In mouse brain, mRNA methylation distinguishes cell subtypes and changes with age. One standout: APP. It loses its methyls over time.
Oligodendrocytes Pump Out Aβ42, Worsening Plaques and Synaptotoxicity
Three new papers report these myelin-producing cells contribute up to a third of plaque Aβ in transgenic mice.
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before Symptoms
A CSF proteomics study in ADAD mutation carriers identified 137 potential markers. They span the AD continuum. For 12 of them, their concentrations change prior to those of classic AD biomarkers.
New Alzheimer’s Gene? Cytochrome P450 Protein Linked to Tangles
In a tau PET GWAS, a SNP linked to higher expression of the oxidizing enzyme was associated with more cortical tangles.
Synaptic Skirmish: Aβ and Tau Pathologies Battle Over Brain Rhythms
Plaques rev up neural oscillations, while tangles turn them down, ultimately leading to sluggish synapses. The slowdown foreshadows symptoms.
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Transcriptomes of more than 400 postmortem brains reveal microglia and astrocyte subtypes that collaborate to precipitate pathologic changes.
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