Proteomics Discerns Sporadic from Familial Alzheimer’s Disease
While each disease features distinct proteomes in the brain, cerebrospinal fluid, and blood, some proteins overlap. They are more dysregulated in familial than in sporadic AD.
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Too Basic: APP β-CTF's YENTPY Motif Binds Proton Pump, Thwarts Lysosomes
In cells from people with Down’s syndrome, and in mouse models of DS and Alzheimer’s, excess β-CTF binds vacuolar ATPase, hobbling lysosomal acidification.
CRISPR Screens Net Tau Partners in Human Neurons, Brain
Two interference screens netted a thousand proteins that affect tau oligomerization. The affected pathways? Mitochondrial malfunction, and UFMylation.
Potential CSF Biomarkers Detect Roused Microglia in AD, FTD
The panel of six marker candidates includes proteins involved in lipid processing and metabolism in microglia.
When Missense Variants Derail SORL1 Traffic, Destination Is Dementia
A trio of studies report that missense variants in SORL1 that disrupt its trafficking or dimerization are highly likely to cause Alzheimer's disease in carriers, strengthening the case for SORL1 being a familial AD gene.
Hundreds of SORL1 Variants Mapped in Alzforum Database; SORL1 Cast as Causal AD Gene
The endocytic receptor SORL1 has come to fruition both literally and figuratively. An interactive diagram of the 2,214 amino acid behemoth—filled with findings about hundreds of rare variants—is live for viewing on the Alzforum Mutations database. A handf
Sorting Out SORL1: 500+ Mutations Mapped, Prioritized in Alzforum Dataset
Functional, genetic, and epidemiological evidence converges on SORL1 as the fourth autosomal-dominant AD gene.
Atlas of Mouse Brain Aging Finds Biggest Changes in White Matter
The comprehensive survey of brain-wide gene expression over the lifespan flagged glial cells in white matter as potential drivers of aging.
Could an RNA-Binding Protein Prevent Tau Aggregation?
When human neurons and brain organoids lack G3BP2, they contain more tau oligomers. The protein binds to tau’s microtubule-binding domain.
Artificial Intelligence Is Everywhere You Look in Dementia Research
As massive, complex datasets burst onto the scene, scientists are using machine learning to analyze the data and uncover hidden patterns. AI may also come in handy in detecting dementia before humans do.
FDA Grants Traditional Approval to Leqembi
The anti-amyloid antibody becomes the first Alzheimer’s treatment in 20 years to receive traditional approval from the FDA. Broader Medicare coverage starts now.
Brain Biopsies and FinnGen Form Wellspring for Functional Genomics
In Kuopio, a collaborative tissue resource supplies the broadest swath of materials found anywhere for functional studies on ADRD genes. Think ABI3, APP, C9ORF72, GRN, PLCG2, TMEM106B—and more.
Cortical Biopsies Hint at Start of Alzheimer's 'Cellular Phase'
Layer 1 interneurons vanish. Layer 2/3 excitatory neurons become hyperactive, then fade. Microglia change state. Astrocytes react. No symptoms yet. Is this preclinical Alzheimer's?
Brain Tissue From Living People with Amyloid Plaques Can Fire in a Dish
Scientists have established acute slice recordings from cerebral cortex biopsies. They find circuitry and basic function to be preserved. They also find changes in the presence of Alzheimer's pathology.
A Day's Work: Cortex Biopsy Comes Out. Shunt Goes In. Patient Goes Home.
Every week in a Finnish operating room, bits of human cortex get lifted from brains and straight into electrophysiology rigs. Other tissues go to diagnostic and research labs, or biobanks, for ADRD research. Read how it happens.
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