Donanemab Confirms: Clearing Plaques Slows Decline—By a Bit
The Phase 2 trial provides the strongest evidence yet that removing most amyloid from the brain bolsters cognition, although the benefit is small.
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The Phase 2 trial provides the strongest evidence yet that removing most amyloid from the brain bolsters cognition, although the benefit is small.
Researchers consider the data encouraging, though questions linger about the cognition results. Did regulators mess up the randomization of this trial?
In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes...
Friends and colleagues grapple with the loss of this young investigator.
Scientists celebrated LaDu's scientific and academic career at Chicago memorial.
These greasy particles carry more than 300 different proteins. Some oil the immune response, inflammation, and wound healing.
The lymphatic-like membrane blankets blood vessels in the subarachnoid space and harbors immune cells.
Vascular troubles preceded amyloid deposition and other disease markers in a new Alzheimer’s progression model based on ADNI data.
The Phase 3 APECS trial of Merck’s flagship BACE inhibitor ends prematurely following an interim safety analysis.
People with subjective or mild cognitive impairment are less likely to get dementia if their CSF Aβ38 levels are high. Should γ-secretase modulators be revived?
Network analysis of human PET brain imaging data suggests amyloid plaques set the stage for microglial activation that, in turn, drives tangle spread through the brain.
Blood and other in vitro assays will need to meet the same standards as medical devices, including demonstrating diagnostic accuracy.
The use of gene expression profiling to characterize Alzheimer disease pathology has, unsurprisingly, focused on...
The results of the AD2000 study of donepezil (Aricept) in Alzheimer's—published in the June 26 Lancet—made a big splash in the media pond. While confirming previous...
Fungal cells cropped up in multiple brain regions of all AD brains examined, but how they got there and what they are doing remains mysterious.