When Faced with Amyloidosis, Human Transplants Die by Necroptosis
In mice, the long noncoding RNA MEG3 mediated the death of human neurons, which accumulated tau tangles.
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Sit Less, Move More to Induce Irisin and Stave Off Dementia
In people over 60, sitting for 12 hours per day increased dementia risk. An exercise-induced hormone, irisin, protects via astrocytes, at least in vitro.
CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers
A curated panel of 48 proteins foretold cognitive decline. It also illuminated biological pathways involved in Alzheimer's disease.
Could Blood Transfusions Transmit Vascular Amyloid?
A retrospective study found an increased risk of brain bleeds in people who received blood from someone else with such bleeds, hinting at a soluble agent. Aβ?
Alzheimer’s Early Detection Challenge Announced
The NIA invites scientists to submit data to create diverse, open datasets and design diagnostic algorithms for more accurate, early prediction of Alzheimer’s.
PLCγ2 Variants Toggle Microglial Plaque Compactors
In a mouse amyloidosis model, a protective variant tightened the reins on plaques and spared synapses; a risk variant did the opposite.
In Alzheimer Brain, Can Synaptic Pruning Be Good?
Provocative new data suggest that glial engulfment of synapses dampens network hyperexcitability early in disease. Key mediators: TREM2 and phosphatidylserine.
Healthy CSF Teems with Diverse Lipoproteins
These greasy particles carry more than 300 different proteins. Some oil the immune response, inflammation, and wound healing.
Lipid-Laden, Sluggish Microglia? Blame Aβ.
Droplets of triglycerides accumulate in microglia exposed to Aβ fibrils. These cells barely ate Aβ, and released molecules that damage neurons.
In 3D Cell Model of AD, Microglia and CD8+ T Cells Gang Up on Neurons
Together, the two immune-cell types deal a neurodegenerative blow more powerful than either can inflict alone.
Alzheimer’s, Primary Age-Related Tauopathy Take Separate Paths
Compared to AD, tau tangles in PART accumulated slowly, and only in the medial temporal lobe. Cognition slipped subtly, and no amyloid amassed over three years.
Direct-to-Consumer Alzheimer’s Blood Test Opens Pandora’s Box
Experts say the low specificity of Quest Diagnostics’ plasma Aβ test could lead to more false than true positives, causing distress and confusion.
Proteins in Biofluids Foreshadow Dementia by 30 Years
Proteins involved in the extracellular matrix, metabolism, immunity, proteostasis, and synaptic function change in the CSF and plasma up to 30 years before dementia sets in.
At the Heart of Alzheimer’s in Down’s: Cerebrovascular Disease
Few people with Down's syndrome have cardiovascular risk factors, yet most develop cerebrovascular disease. Will this complicate anti-amyloid immunotherapy?
Goodbye, APOE4. Hello, Healthy Brain?
Two men with loss-of-function variants in their APOE4 alleles escaped amyloid pathology. One was in his 90s.
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