From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
Mice have a small pool of such Tregs. Removing them hobbles the hippocampus, beckons immune invasion, revs glia, and quashes neurogenesis.
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ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
In AD mouse models, replacing ApoE3 with ApoE3Ch preserves memory.
Leqembi Maintenance Dosing Approved in the U.S.
The nod will allow people who have completed 18 months of biweekly IV dosing to transition to monthly IVs. An application for subcutaneous dosing is pending.
C-Terminal Amidation Sends Proteins to the Shredder
Triggered by oxidative stress, this degradation signal may protect neurons.
Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
By tracking how mutations influence the incorporation of monomers, scientists pinpoint which residues shape tau fibrils.
Blame Mom? Maternal X Chromosome Worsens Memory
In female mice, the silencing of several cognitive genes on maternally inherited X chromosomes correlated with poor memory; re-expressing the genes improved it.
Can the Kidneys Kickstart Parkinson’s?
In people with PD and other Lewy body diseases, α-synuclein accumulates in the kidneys, scientists say. In mice, it spreads from there to the brain.
“iAssembloids” Probe Glial Roles in Neuron Survival
New 3D model shows how a tau kinase and Apoe4 astrocytes kill neurons through oxidative stress.
Plaques Spur Spread of Tangles by Sending Synapses into Overdrive
Hyperconnectivity ushers tangles from temporal lobe to posterior cortex. Study could revive interest in trialing anti-convulsants with tau biomarkers as an outcome.
Another γ-Secretase Binding Partner Implicated in Aβ Production
Cell survival factor EBP1 binds the enzyme’s presenilin subunit, interfering with APP binding and lowering Aβ output. EBP1 drops with age and in AD brains.
Lactylation—a New Protein Modification That Slows Alzheimer’s?
In mice, lactylation of APP reduces amyloid deposits and slows disease progression.
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Recent genetic and mechanistic studies on SORL1 place the endolysosomal system, in both neurons and microglia, front and center in the pathogenesis of AD.
Inhaled Xenon for AD?
In models of amyloidosis and tauopathy, the noble gas curbed inflammation and made microglia more phagocytic, resulting in fewer aggregates and healthier neurons.
New Atlas Catalogues Regulatory RNA Changes in Alzheimer’s
Survey of post-translationally modified and noncoding RNA identified more than 25,000 differences between AD and control brain.
Does the Brain Make Phospho-Tau to Fight Viruses?
In AD brain, cells ramp up expression of herpes virus proteins. In cultured neurons, these proteins boost p-tau, which then suppresses viral proteins.
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