Donanemab: Small Tweak in Titration, Big Gain in Safety?
By starting at a low dose and upping it step by step for the first four months, scientists nearly halved the risk of ARIA while preserving plaque clearance.
NEWS
Trontinemab Data Strengthen Hope for Brain Shuttles
Trontinemab efficiently swooped into the brain and removed amyloid, while instigating minimal ARIA. One participant with cerebrovascular pathology died.
That Mystery “Density” in α-Syn Fibrils: Polyphosphate, Anyone?
Computer modeling and recombinant protein chemistry suggest that strings of phosphate worm their way through the fibrils. Proof is still needed.
Remembering Bruce Albala, 70, Leader in BACE Inhibitor Development
Albala died suddenly while celebrating his 40th wedding anniversary.
Lysosomal Protein TMEM106b Is Tightly Linked to TDP-43, Tau Pathology
Neurons with TMEM106B aggregates lose nuclear TDP-43 in ALS models. In tauopathy models, they accumulate no p-tau.
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding Plaque
The fateful pairing may happen in microglial lysosomes, where ApoE forms fibrillar aggregates.
Some Plasma Proteins Bolster Phagocytosis and Metabolism in Microglia
In certain regions of the brain, microglia internalize proteins from the plasma. At least one of them—ApoA-I—supports microglial phagocytosis.
Amyloid Plaques Turn More Toxic as They Age
Combining isotopic labeling and transcriptomics, scientists found that mature plaques in mice wreaked more havoc on surrounding synapses than immature ones.
SPOTLIGHT
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding Plaque
Most scientists agree that for amyloidosis to ignite, both ApoE and microglia need to be present. A new study presents a mechanistic link between the two. Scientists report that ApoE and Aβ both aggregate within microglial lysosomes, and that these intracellular liaisons ultimately seed amyloid plaques.
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