Tau-PET and P-tau217—Equally Predictive, Yet Complementary
In a head-to-head comparison, the two markers similarly predicted cognitive decline in healthy people. Still, using them sequentially might best identify who will benefit from therapy.
NEWS
Do Synaptic Markers Foreshadow Cognitive Decline?
Ratio of two peptides in cerebrospinal fluid increases with age, a change accelerated by Alzheimer’s disease.
Donanemab Clinical Use Growing in U.S., Rejected in Europe
Donanemab prescriptions have been slow to ramp up, but demand is growing due to an easier dosing schedule than for lecanemab.
Plaque Removal Delays Onset of Familial Alzheimer’s Disease
Healthy people who carry an autosomal-dominant AD mutation halved their odds of developing symptoms when they took gantenerumab for eight years.
Filling in the Family Tree: AD, CTE Folds Spotted in Other Tauopathies
Core structures of protofilaments from more diseases prompt an update to the family tree of tau filaments.
Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes.
Dementia prevalence has come down nearly 3 percent per year for the last 40 years, with each successive birth cohort less likely to succumb.
Mobile Devices Track Brain Health in 23,000 People
In the largest study of its kind, volunteers took cognitive tests on their devices and had their app usage monitored. Baseline data flagged people with MCI.
Eat Well, Stay Trim—Your Brain Will Thank You Later
People who ate a healthy diet and carried less abdominal fat in midlife had better-working brains 20 years later, according to MRI scans.
SPOTLIGHT
Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes.
Could predictions of a doubling of U.S. dementia cases by 2050 be overblown? A provocative new analysis suggests so, finding that the age-adjusted prevalence of dementia has dropped by two-thirds in the last 40 years as public health improved. That projects to only 25 percent more dementia in 2050, even with an aging population. Will positive health trends continue, or will rising obesity and diabetes reverse them?
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