Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Recent genetic and mechanistic studies on SORL1 place the endolysosomal system, in both neurons and microglia, front and center in the pathogenesis of AD.
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SPOTLIGHT
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Mutations that slow SORL1 trafficking through the cell associate with AD, and recent work helps unveil the mechanisms involved. In neurons, SORL1 deficiency hobbles endosomal network, compromising recycling of proteins such as APP and synaptic receptors. In microglia, lysosomes suffer the consequences, accumulating undigested contents as crucial proteases get trapped in the trans-Golgi network. Check out Alzforum’s update to learn more about the latest science on this massive sorting receptor.
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