Trontinemab Fuels Hope for Brain Shuttle Lift-Off
The transferrin receptor-targeted, anti-Aβ antibody swiftly cleared amyloid throughout the brain. It caused little ARIA, though lots of infusion reactions.
NEWS
Will We Soon Stage Alzheimer’s With Plasma Markers?
Tau fragments, alone or with other proteins, can help identify people with high tangle burden. This could help select people for trials or therapy.
Blood Tests: Not Just for the Impaired?
Real-world data hints that plasma markers can pick up Alzheimer’s pathology before people have memory complaints.
Looking Good: Immunoassays for Blood Markers
Fully automated test may be as accurate as mass spec, and more scalable
Tau PET as Progression Marker: It’s the Spread, Not the Brightness
The spatial extent of tau pathology better correlates with disease severity, and stages disease more accurately, than does tangle load.
Commander Complexes in Lysosomes Stave Off Parkinson’s Risk
Decreased lysosomal efficiency could result from shifts in endosomal recycling.
Trial-Eligible Genetic Variants Now Marked in Alzforum Mutations Database
DIAN-TU explains how it selects APP, PSEN1, and PSEN2 genetic variants for clinical trial inclusion.
Trialists Grapple with How to Outsmart TREM2
After one TREM2 agonist antibody nose-planted, a new batch of therapies appear safe so far in first-in-human data. The drugs exert different effects on the receptor and soluble TREM2.
SPOTLIGHT
TREM2 and Tau News from AD/PD
Our next batch of news reports from the 30th AD/PD conference in Vienna brings you a twisting tale of findings about the important microglial receptor TREM2, as well as a story about efforts to track tau’s spread through the Alzheimer’s brain as a way to measure drug effect. Stay tuned this week for more news about how tau-based plasma tests are diversifying as they approach staging, real-world study, and FDA approval. Meanwhile, DIAN and Alzforum have added trial-eligibility information to APP and PS1/PS2 pathogenic mutations.
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