Lysosomal Protein TMEM106b Is Tightly Linked to TDP-43, Tau Pathology
Neurons with TMEM106B aggregates lose nuclear TDP-43 in ALS models. In tauopathy models, they accumulate no p-tau.
NEWS
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding Plaque
The fateful pairing may happen in microglial lysosomes, where ApoE forms fibrillar aggregates.
Some Plasma Proteins Bolster Phagocytosis and Metabolism in Microglia
In certain regions of the brain, microglia internalize proteins from the plasma. At least one of them—ApoA-I—supports microglial phagocytosis.
Amyloid Plaques Turn More Toxic as They Age
Combining isotopic labeling and transcriptomics, scientists found that mature plaques in mice wreaked more havoc on surrounding synapses than immature ones.
New Role for Tau: Making Lipid Droplets in Glia?
Glia need exactly the right amount of tau for lipid droplets to bud from the endoplasmic reticulum. The droplets soak up toxic lipids spilled by stressed neurons.
Lecanemab Bested Three Other Antibodies at Binding Soluble Aβ Aggregates
In a head-to-head comparison with aducanumab, gantenerumab, and donanemab, lecanemab had the highest affinity, especially for smaller aggregates.
Can Heparin Delay Alzheimer’s Disease?
In two hospital systems, people who received heparin were diagnosed with AD a year later than people who never took the anticoagulant.
Data Fabrication Ousted NIA Neuroscience Director Eliezer Masliah
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face allegations.
SPOTLIGHT
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding Plaque
Most scientists agree that for amyloidosis to ignite, both ApoE and microglia need to be present. A new study presents a mechanistic link between the two. Scientists report that ApoE and Aβ both aggregate within microglial lysosomes, and that these intracellular liaisons ultimately seed amyloid plaques.
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