Some Plasma Proteins Bolster Phagocytosis and Metabolism in Microglia
In certain regions of the brain, microglia internalize proteins from the plasma. At least one of these peripheral proteins—ApoA-I—supports microglial phagocytosis.
In certain regions of the brain, microglia internalize proteins from the plasma. At least one of these peripheral proteins—ApoA-I—supports microglial phagocytosis.
Combining isotopic labeling and transcriptomics, scientists found that mature plaques in mice wreaked more havoc on surrounding synapses than immature ones.
Glia need exactly the right amount of tau for lipid droplets to bud from the endoplasmic reticulum. The droplets soak up toxic lipids spilled by stressed neurons.
In a head-to-head comparison with aducanumab, gantenerumab, and donanemab, lecanemab had the highest affinity, especially for smaller aggregates.
In two hospital systems, people who received heparin were diagnosed with AD a year later than people who never took the anticoagulant.
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face allegations.
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
A whole-genome sequencing study estimated that people are two to three times more likely to be affected by these mutations than predicted by epidemiology.
When neurons are overwhelmed by oxidative stress, they spew out peroxidized lipids, which are promptly mopped up by nearby glia. According to new research, tau play a pivotal role in this clean-up. In binding microtubules, it helps lipid droplets bud from the glial endoplasmic reticulum. Too much or too little tau impedes this process.
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