An Idiosyncratic View of AD Biomarkers

15 Jun 2006

Media Player (PC Mac) to view this presentation. Paul Coleman led this Webinar on 1 June 2006. Readers

Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look

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12 Apr 2006

Vikram Khurana, Karl Herrup, Bruce Lamb, Inez Vincent, Rachael Neve, Donna McPhie, Dan Geschwind, Cathy Andorfer, and Xiongwei Zhu participated in a discussion of how far the cell cycle hypothesis has come in the past few years, and where to go next. Vik

Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

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25 Mar 2006

We invite you to participate in this “offline” Forum discussion with past ARF advisors Peter Davies of Albert Einstein College of Medicine in the Bronx, New York, and Bart De Strooper at K.U. Leuven, Belgium. The goal of this discussion is to explore the

Not Dead Yet: Estrogen Deserves Another Chance

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28 Jan 2006

You may think the Women’s Health Study has sounded the death knell for estrogen replacement therapy, but actually, the idea is showing new signs of life. A second-generation approach with better compounds may warrant continued investment, and yet, how doe

The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

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22 Jan 2006

We invite you to participate in this "offline" Forum Discussion led by Brian Balin (Philadelphia College of Osteopathic Medicine). This discussion will extend our previously held live discussion on the Pathogen Hypothesis of Alzheimer Disease. T

Reducing the Risk of Alzheimer Disease

23 Dec 2005

The topic is an apt one to launch the new year: what factors in daily life can reduce one's risk of Alzheimer's disease? To fire up your neural networks, you are invited to read the recent review (download pdf) by Kathryn Jedrziewski, Virginia L

Are Glia Active Participants in Neurodegenerative Disease?

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05 Dec 2005

Ben Barres led the first in a series of Alzforum discussions about the role of glial cells in Alzheimer’s and other neurodegenerative diseases. It has become trendy to say that glia are more than just glue, but in reality, science has not yet advanced sig

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

In a paper just published in the inaugural issue of the new journal, Alzheimer's & Dementia, Claudio Costantini, Rekha Kolasani, and Luigi Puglielli argue that the lipids ceramide and cholesterol may provide metabolic links between AD and aging.

Lost in Translation? Charting the Course in Preclinical Therapeutic Development: A Panel Discussion

15 Oct 2005

See also our Drug Development Database and Tutorial. Howard Fillit, Jordan Tang, Frank Longo, Eli Michaelis, and Jens Eckstein led this live discussion on 16 September 2005. Readers are invited to submit additional comments by using our Comments form at t

Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research?

14 Oct 2005

This live discussion was held on the paper by O'Doherty et al., in Science, on "An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes." Lizzy Fisher and Victor Tybulewicz led this live discussion on 14 October

Insulin Resistance: A Common Axis Linking Alzheimer's, Depression and Metabolism?

06 Jul 2005

Our thanks to the Journal of Gerontology for granting permission to post the full text article. Natalie Rasgon led this live discussion on 6 July 2005. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.

100 Questions and Answers About Alzheimer's Disease

01 Jul 2005

Are you a physician or caregiver thirsting for an update on the latest research on Alzheimer disease, or are you a basic researcher curious about the latest advances in clinical diagnosis and care?   Tom Wisniewski and Marcin Sadowski led this live discus

Differential Neuronal Vulnerability

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29 Jun 2005

Vikram Khurana and Ole Isacson led this live discussion on 29 June 2005. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live Discussion led by Ole Isacson and Vikram Khurana on 29 June 2

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

Ever since amyloid-β (Aβ) was identified as the major component in amyloid plaques, scientists have been trying to decipher just exactly what the little peptide does. Most researchers would agree that Aβ is toxic to cells, but some are still skeptical. Ev

Making a BioMark on Alzheimer Disease

01 Jun 2005

Our thanks to Practical Neurology for granting permission to reprint the full text of a recent article (.pdf) by John Trojanowski. John Trojanowski, Les Shaw, and Anne Fagan led this live discussion on 1 June 2005. Readers are invited to submit additional