RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

years ago there was a Nature Cell Biology paper showing knockout phenotypes with RNAi very early in

Finding NIH Support for Drug Discovery and Development for Neurodegenerative Diseases

• 2 Comments

09 Apr 2007

Searching for the wherewithal to push on with your work on a promising new Alzheimer therapy? The NIH offers funding for research support at every step of the process, from early drug discovery right through to phase 3 clinical trials, if you know where t

The AD8—Dementia Screen Ready for Prime Time?

• 6 Comments

02 Dec 2010

Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against neuropsy

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

1985)? Bruce Kagan David, I'm not familiar with this paper. Do you think it might be evidence of Aβ

Microdissection and Microarrays: Analyzing Selective Cell Vulnerability

• 2 Comments

16 Sep 2010

As Tolstoy wrote in Anna Karenina, “Happy families are all alike; every unhappy family is unhappy in its own way.” The same might be said of the brain. Normal brains look and behave similarly, but those affected by different neurodegenerative diseases are

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

We invite you to participate in this Forum Discussion with Yong Shen (Sun Health Research Institute). This discussion will not be hosted via our live discussion software. Instead, we will develop written exchanges between our participants and Yong Shen. T

The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

• 5 Comments

22 Jan 2006

We invite you to participate in this "offline" Forum Discussion led by Brian Balin (Philadelphia College of Osteopathic Medicine). This discussion will extend our previously held live discussion on the Pathogen Hypothesis of Alzheimer Disease. T

Intracellular Aβ in Alzheimer's Disease

• 3 Comments

16 May 2000

Gunnar Gouras led this live discussion on 16 May 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 16 May 2000.   Participants: Bruce Yankner, Huaxi Xu, Austin Ya

Grasping the Shadow Force: Immune Cells in ALS

• 1 Comment

12 May 2011

When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists t

Caloric Restriction: Eat Less, Live Longer!

• 4 Comments

31 Mar 2005

We invite you to participate in this Forum Discussion with Matt Mattson (National Institute on Aging). This discussion will not be hosted via our live discussion software. Forum discussions invite written exchanges between our participants and the discuss

Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis

• 20 Comments

01 Nov 2006

We invite you to participate in this "offline" Forum discussion led by Vincent Marchesi of Yale University. Coming from a different research field, Marchesi has in recent years followed the AD literature as closely as have few other outside obse

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

Live discussion and panel of participants scheduled for 7 September 2001.     Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe