Beta-Catenin and PS1
signalling. I thought that we might open the forum with a brief discussion about why papers have demonstrated
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Protofibrillar Aβ in Alzheimer's Disease
Dean? William Klein: Let me start by saying how much I enjoyed the paper by Dean et al. A good read.
Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein
postmortem? Luciano: We reported in our JAD paper the isolation of AID-like peptides from the brains of normal
New Theories of Presenilin Function
Dr.Thinakaran, firstly we should show what is the problem between our paper and Sato's paper (Nature Cell
The Role of ApoE in Alzheimer's Disease: An Alternative View
Mesulam, 1999; Lue et al, 1999; Koudinov et al, 2001.) Also, a recent paper by a Scottish group (White, et
Neural Stem Cells to the Rescue—Can Neuroreplacement Ever Become a Treatment for Alzheimer's?
a longer answer; check our papers and I will talk with you about that answer later. Bye. Kiminobu Sugaya:
Alzheimer Genes in Cortical Development: How Do Their Prenatal Functions Relate to Dementia?
Hiroko, Marc is not the only one who has done work on this. I believe there are over 30 papers on the
From Here to There: AβPP as an Axonal Transport Receptor—How Could This Explain Neurodegeneration in AD?
Larry, how do you connect your cytoplasmic events with nuclear events? (See related paper.) To be more
Will Probing Flies and Worms Bear Fruit in the Search for New Genes Involved in Alzheimer's?
Orlando, I suppose... I have read your recent paper, Chris, and am excited to have you join us. Chris Link
RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?
years ago there was a Nature Cell Biology paper showing knockout phenotypes with RNAi very early in
Cholinergic Plasticity in Hippocampus of Individuals with Mild Cognitive Impairment: Correlation with Alzheimer's Neuropathology
in the Journal of Alzheimer's Disease, which is making the full text (.pdf) of these papers
Therapeutic Nihilism: Widespread Yet Passé? AD Acetylcholinesterase Inhibitors Are Better Than Their Reputation
papers details potential benefits of the cholinesterase inhibitors, with the data for each being
Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?
not all present here today have had a chance to read your latest paper yet. Everyone, while Stefan is
Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?
Neurology paper we reported that the side effects were not remarkable. Previously, clioquinol (CQ) was
Stem Cell Therapies for Neurodegenerative Disease: How Should We Push Ahead?
Rao, are you as depressed as I am about those two Nature papers that just came out showing a failure of
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
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