The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus

21 Dec 2006

some role in the nucleus? Tom Fagan All, there's a paper coming out in this week's Cell from

Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis

• 20 Comments

01 Nov 2006

We invite you to participate in this "offline" Forum discussion led by Vincent Marchesi of Yale University. Coming from a different research field, Marchesi has in recent years followed the AD literature as closely as have few other outside obse

M1 Receptors Play a Central Role in AD Pathology and Cognition

05 Jul 2006

Our thanks to Neuron for providing free access to this paper for the purposes of this live

Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look

• 4 Comments

12 Apr 2006

upstream of apoptosis, as we argue for in the Current Bio paper. Inez Vincent Karl, yours is a good point,

Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

• 23 Comments

25 Mar 2006

Leuven, Belgium. The goal of this discussion is to explore the implications of two recent papers, which

Not Dead Yet: Estrogen Deserves Another Chance

• 1 Comment

28 Jan 2006

correct. Mark Smith Phyllis, I have read in several papers otherwise...we should discuss. Sam Gandy I was

The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

• 5 Comments

22 Jan 2006

We invite you to participate in this "offline" Forum Discussion led by Brian Balin (Philadelphia College of Osteopathic Medicine). This discussion will extend our previously held live discussion on the Pathogen Hypothesis of Alzheimer Disease. T

Reducing the Risk of Alzheimer Disease

23 Dec 2005

latest paper on the p25 mice, this month, is summarized at ARF (see ARF related news story). No sirtuin

Are Glia Active Participants in Neurodegenerative Disease?

• 1 Comment

05 Dec 2005

Ben Barres Wenan, Mike Sofroniew’s paper shows that reactive gliosis is important in keeping neurons

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

In a paper just published in the inaugural issue of the new journal, Alzheimer's &

Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research?

14 Oct 2005

This live discussion was held on the paper by O'Doherty et al., in Science, on "An

Insulin Resistance: A Common Axis Linking Alzheimer's, Depression and Metabolism?

06 Jul 2005

2000 Jul 15;25(14):1765-70. Abstract 0 we have pdf of paper Wednesday, July 6, 2005- 00:00

100 Questions and Answers About Alzheimer's Disease

01 Jul 2005

regarding your peptide inhibitor (see Sadowski et al., 2004)? In your paper, your peptide inhibits the

Differential Neuronal Vulnerability

• 2 Comments

29 Jun 2005

(mediated by gene expression differences as shown so well in this paper) to different insults. Once we

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

1985)? Bruce Kagan David, I'm not familiar with this paper. Do you think it might be evidence of Aβ