Memantine: Implications for Treating Alzheimer's

29 Sep 2004

effects (see Orgogozo et al., 2002 and Wilcock et al., 2002). John C. Morris Bengt, Lon, Steve, Gabrielle,

A "Mitochondrial Cascade Hypothesis" for Sporadic Alzheimer's Disease

24 Sep 2004

(Nunomura et al., 2004) showing that where Aβ exists, there is actually less evidence of oxidative stress in

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

(Aloyz et al., 1998; Ashkenazi et al., 1998). Death domain sequences vary slightly between receptors, but

Cast Call for Players: Healthy Aging Through Lean Living

17 Aug 2004

was no different than that of the animals fed ad libitum every day (see Anson et al., 2003). Howard

Alzheimer's Disease: A Re-examination of the Amyloid Hypothesis

• 1 Comment

30 Jul 2004

apoptosis even when Aβ 42 was not produced from them. Peter Nelson: And yet, La Ferla et al. showed that

Protein Misfolding: An Unfolding Series of Discussions

09 Jun 2004

decreases in proteasome activity in AD (Keller et al., 2000 and Keck et al., 2003, but has anyone looked

Androgens, ApoE, and Alzheimer's Disease

• 1 Comment

07 May 2004

This discussion was produced in collaboration with SAGE KE. Jacob Raber led this live discussion on 7 May 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript unavailable. Background Text

Vascular Factors in Alzheimer's Disease

21 Apr 2004

but not by apoptosis (we discussed this in Science/Nature several years ago, see Perry et al 1998 and

Stem Cell Therapies for Neurodegenerative Disease: How Should We Push Ahead?

30 Mar 2004

One was from my colleague Chuck Murry (see Murry et al., 2004), and the other involved Irv Weissman

Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?

15 Jan 2004

Indirect evidence is there. APP translation is regulated by iron (Rogers et al., 2002). Alexei Koudinov

Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?

17 Dec 2003

See Harrison et al., 2003.] Stefan Lichtenthaler Gabrielle, this brings us to the question of

Is Alzheimer's an Autoimmune Disease?

• 1 Comment

04 Dec 2003

neurons that light up. Dara Dickstein We have recently published in Microcirculation (Ujiie et al., 2003)

BDNF and Alzheimer's Disease—What's the Connection?

25 Nov 2003

levels of synaptic vesicle proteins (Martinez et al., 1998; Pozzo-Miller et al., 1999), demonstrating

Alzheimer's: A Triple Whammy. Why are So Many Neurodegenerative Diseases Single, Double, or Triple Amyloidoses?

• 1 Comment

22 Oct 2003

concept of synaptic apoptosis developed by Mattson et al., 1998 John Q. Trojanowski One would assume

Therapeutic Nihilism: Widespread Yet Passé? AD Acetylcholinesterase Inhibitors Are Better Than Their Reputation

14 Oct 2003

need such a lesson and do have to depart). Pete Nelson Thanks for the chat, Gabrielle et al.; it was