Is Alzheimer’s Disease a Uniquely Human Disorder?
e.g., Bussiere et al., 2003). Brain regions giving rise to long axonal connections have expanded in
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Webinar: Pathogenic Protein Spread? Let’s Think Again
that propagate may not always cause dysfunction (e.g., Liu et al., 2015). Rather, dysfunction may arise
Suzanne Hendrix on Constructing Composites for Trials in Early Alzheimer’s
Have you ever been jolted wide awake by—biostatistics? That’s what happened on the last morning of the Clinical Trials on Alzheimer’s Disease conference held November 5-7 in Barcelona, Spain. At 8 a.m., as sleepy CTADeers slowly shuffled in, Suzanne Hendr
Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?
organelles that store mRNAs and related proteins (Gilks et al., 2004; Decker et al., 2007). These organelles
Computational Modeling—Will it Rescue AD Clinical Trials?
simulation tool (CTS) (see Jul 2013 news and Rogers et al., 2012). Klaus Romero and colleagues at CAMD
Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?
Cullen et al., 2005; Goos et al., 2009; and Feb 2014 news). Iron, possibly from the breakdown of
Mutations Impair TREM2 Maturation, Processing, and Microglial Phagocytosis
In the July 2 Science Translational Medicine, an international group of scientists reported how TREM2 missense mutations linked to neurodegenerative diseases impair the protein's function. The mutations prevent TREM2 from reaching the cellular surfac
Good-Bye Overexpression, Hello APP Knock-in. A Better Model?
atrophy (see Higuchi et al., 2012). While this seemed plausible at the time, crossing NL-F mice with
Neurovascular Underpinnings of Alzheimer's Dementia
vascular disease from the diagnosis (McKhann et al., 1984), while vascular dementia was considered
Webinar: O Blood-Based Biomarker, Where Art Thou?
reflect Alzheimer’s disease in the brain (see review by Toledo et al., 2013). Attempts to correlate other
Can Network Analysis Identify Pathological Pathways in Alzheimer’s
this approach to identify molecular modules that might contribute to metabolic syndrome (Chen et al.,
New Frontier: Developing Outcome Measures for Pre-dementia Trials
See questions answered by Suzanne Hendrix As researchers push into the frontier of early-stage and preventative Alzheimer's disease clinical trials, they will have to measure whether a drug works in people who do not have dementia yet. Traditional ou
How Cognitive Stimulation Might Protect Against Aβ Oligomers
accumulate less amyloid in the brain (see ARF related news story; Arendash et al., 2004; Jankowsky et al.,
Neuroinflammation—A Prelude to Alzheimer's?
story and Breitner et al., 2011). Some researchers in the field have not given up hope that reining in
Latest γ-Secretase Substrate Involved in Synaptic Stability, Autism?
Südhof, 2008, review; Yanagi et al., 2012; Sun et al., 2011; Qi et al., 2009). Two papers in the October
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