Alzheimer's Disease: A Re-examination of the Amyloid Hypothesis

• 1 Comment

30 Jul 2004

Peter Nelson led this live discussion on 26 March 1998. Readers are invited to submit additional

Vascular Factors in Alzheimer's Disease

21 Apr 2004

changes in Alzheimer's disease and other dementias. Ann N Y Acad Sci. 1997 Sep 26;826:7-24. Review.

Stem Cell Therapies for Neurodegenerative Disease: How Should We Push Ahead?

30 Mar 2004

of hippocampal memory traces. Neuron. 2001 Dec 6;32(5):911-26. Erratum in: Neuron 2002 Jan

Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?

15 Jan 2004

Radic Biol Med. 2001 Jan 1;30(1):119-28. Abstract 26. Kontush A, Donarski N, Beisiegel U. Resistance of

Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?

17 Dec 2003

M, Dohmae N, Takio K, Saido TC, Hashimoto Y. Characterization of alpha 2,6-sialyltransferase cleavage

Alzheimer's: A Triple Whammy. Why are So Many Neurodegenerative Diseases Single, Double, or Triple Amyloidoses?

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22 Oct 2003

John Q. Trojanowski and Mark P. Mattson discussed the major commonality between many neurodegenerative diseases. Otherwise vastly different conditions that run the gamut from Alzheimer's, Parkinson's, Huntington's, ALS, to prion disorders,

Are Neurons Just Too Laissez-Faire about Repair?

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24 Jul 2003

Thierry Nouspikel led this live discussion on 14 July 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Dr. Thierry Nouspikel led this live discussion on 14 July 2003. Moderated by Dr

How Does Excess Aβ Leave the Brain, How Does It Get In, And Can We Trap It Outside?

• 1 Comment

23 Jun 2003

Neurobiol Dis. 1997;4:27-34. Abstract 26. Poduslo JF, Curran GL. Amyloid-b peptide as a vaccine for

Axonal Transport Hypothesis Moves On to Implicate Presenilin

• 1 Comment

17 Jun 2003

This live discussion is an update of last year's initial Live Discussion of axonal transport as an underlying factor in neurodegeneration. Jorge Busciglio and Scott Brady led this live discussion on 17 June 2003. Readers are invited to submit additio

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

Cell. 1998 Dec 23;95(7):1017-26. Abstract Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L,

Intraneuronal Aβ Accumulation—More Evidence, Less Controversy?

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26 Nov 2002

Gunnar Gouras led this live discussion on 26 November 2002. Readers are invited to submit

Cholesterol and Alzheimer's—Charging Fast But Still at a Distance from Solid Answers

• 3 Comments

19 Nov 2002

genetics issue is covered in our Neurobiology of Lipids abstracts article Frankfurt, Germany Meeting (26

Will Probing Flies and Worms Bear Fruit in the Search for New Genes Involved in Alzheimer's?

29 Oct 2002

26;92(20):9368-72. Abstract Fonte V, Kapulkin V, Taft A, Fluet A, Friedman D, Link CD. Interaction of intracellular

How the Other Half Lives—Or the What, How, and Where of the AβPP Intracellular Domain

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20 Sep 2002

Frank LaFerla led this live discussion on 20 September 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 20 September 2002, featuring Frank LaFerla of the Univers

β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease

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12 Sep 2002

Malcolm Leissring and Wesley Farris led this live discussion on 12 September 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 12 September 2002 with Wesley Farri