Isolation of Single Immunohistochemically Identified Whole Neuronal Cell Bodies from Post-Mortem Human Brain for Simultaneous Anlaysis of Multiple Gene Expression

27 Feb 1998

for G3PDH and now we use primers for 18s ribosomal RNA and the rate of positives is roughly 50 percent

Probing PPARγ? Agonists: Could Diabetes Drugs Treat Alzheimer's Disease?

• 1 Comment

16 Dec 2002

with 30 patients. The study uses pioglitazone at 45 mg/day for 18 months. The primary outcome measures

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

20 Mar 1998

Marc Paradis led this live discussion on 20 March 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper under Discussion: Li JH, Xu M, Zhou H. Ma J. and Potter H. Alzheimer presenilins in the n

Herpes Simplex and Alzheimer’s—Time to Think Again?

• 14 Comments

15 Apr 2011

On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared som

Not Dead Yet: Estrogen Deserves Another Chance

• 1 Comment

28 Jan 2006

that leuprolide increased longevity in rats by 18 percent with 6 months of treatment. Mark Smith Craig,

Early Detection of Alzheimer Disease—A Virtual Town Hall Meeting

• 1 Comment

09 Jul 2008

disease. Q: Does anyone believe PET imaging, perhaps with F-18 amyloid tracers, will be clinically

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

15;18:2801-2807. Abstract. 2. Campbell HD, Webb GC, Fountain S, Young IG. The human PIN1 peptidyl-prolyl cis/trans

Is Alzheimer's an Autoimmune Disease?

• 1 Comment

04 Dec 2003

of autoantibodies occur in control and AD serum. This may be changing now. A recent study of 18 AD

Differential Neuronal Vulnerability

• 2 Comments

29 Jun 2005

dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiol Dis, 18, 19-31.

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

Ever since amyloid-β (Aβ) was identified as the major component in amyloid plaques, scientists have been trying to decipher just exactly what the little peptide does. Most researchers would agree that Aβ is toxic to cells, but some are still skeptical. Ev

Meet New Players, Histone Deacetylase and Sirtuin—Will They Help the Cell Cycle, DNA Repair, and Gene Expression Break Into Alzheimerology’s Major League?

• 2 Comments

10 Feb 2009

but alters gene expression during aging. Cell. 2008 Nov 28;135(5):907-18. Abstract 0 Thursday,

Who Should Use the New Diagnostic Guidelines? The Debate Continues

13 Jan 2012

cortex on              [18]flurodeoxyglucose (FDG) positron emission tomography         c) atrophy on MRI

Stem Cell Therapies for Neurodegenerative Disease: How Should We Push Ahead?

30 Mar 2004

2003 Nov;18(10):2707-12. Abstract Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E. Neurogenesis

Vascular Disease, Parkinson's, and Now Alzheimer's—Is Homocysteine the New All-Around Bad Guy?

• 1 Comment

12 May 2002

deficiency in AβPP-mutant mice in old age of your mice (about 18 months), but before amyloid deposition? Just

Beta-Catenin and PS1

13 Aug 1999

Chris Weihl, with Bruce Yankner, Benjamin Wolozin, Eddie Koo, and Kenneth Kosik led this live discussion on 13 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion