Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AAV-GAD | AAV-GAD2, NLX-P101 |
Parkinson's Disease (Phase 1/2) | MeiraGTx Limited | Other Neurotransmitters | DNA/RNA-based | |
| ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| ACP-204 | Alzheimer's Disease (Phase 2/3) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | ||
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
| ALX-001 | BMS-984923 | Alzheimer's Disease (Phase 1) | Allyx Therapeutics, Inc. | Amyloid-Related, Other Neurotransmitters | Small Molecule | |
| Aripiprazole | Abilify, BMS-337039 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
| AVP-786 | Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | ||
| AVP-923 | Nuedexta, Zenvia |
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) | Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | |
| AXS-05 | Dextromethorphan/bupropion, Auvelity |
Alzheimer's Disease (Phase 2/3) | Axsome Therapeutics, Inc. | Other Neurotransmitters | Combination, Small Molecule | Major depressive disorder |
| Bemdaneprocel | BRT-DA01, MSK-DA01 |
Parkinson's Disease (Phase 1) | Bayer, BlueRock Therapeutics | Other Neurotransmitters, Other | Other | |
| Besipirdine HCl | HP 749 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| Brexpiprazole | Rexulti, OPC 34712 |
Alzheimer's Disease (Approved), Schizophrenia (Approved) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Cannabidiol | CBD, Epidiolex |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex | |
| Citalopram | escitalopram, Celexa, Lexapro , Cipralex |
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) | Other Neurotransmitters | Small Molecule | Depression, generalized anxiety disorder | |
| CST-103 | Clenbuterol | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) | Other Neurotransmitters | Small Molecule | Asthma, in countries outside the U.S. | |
| CST-2032 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) | CuraSen Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | ||
| CVN424 | Parkinson's Disease (Phase 2) | Cerevance | Other Neurotransmitters | Small Molecule | ||
| CX516 | Ampalex | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | None |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Dimebon | Dimebolin, Latrepirdine, Pf-01913539 |
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) | Medivation, Inc. | Other Neurotransmitters, Unknown | Small Molecule | Anti-histamine use in Russia |
| Dipraglurant | ADX48621 | Parkinson's Disease (Discontinued) | Addex Therapeutics | Other Neurotransmitters | Small Molecule | |
| Dronabinol | THC , Marinol, Syndros, delta-9-tetrahydrocannabinol, delta-9-THC |
Alzheimer's Disease (Phase 2) | AbbVie, Others | Other Neurotransmitters | Small Molecule | Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy |
| GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| Guanfacine | Intuniv, SPD503, Afken, Estulic, Tenex |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder, hypertension | |
| Iclepertin | BI 425809 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 3) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | |
| Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Intepirdine | RVT-101, SB 742457 , GSK 742457 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| Kynmobi | APL-130277, apomorphine hydrochloride sublingual thin film |
Parkinson's Disease (Approved) | Sunovion Pharmaceuticals Inc. | Other Neurotransmitters | Small Molecule | |
| Levodopa | L-Dopa, Sinemet, Duodopa, Duopa, Inbrija, Parcopa, Prolopa, Rytary, Stalevo, Foslevodopa |
Parkinson's Disease (Approved) | AbbVie, Acorda Therapeutics, Inc., Amneal Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| Lumateperone | ITI-007 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | |
| Masupirdine | SUVN-502 | Alzheimer's Disease (Phase 3) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | |
| Memantine | Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® |
Alzheimer's Disease (Approved) | Forest Laboratories, Inc., Lundbeck, Merz Pharma | Other Neurotransmitters | Small Molecule | Alzheimer's Disease |
| Methylphenidate | Ritalin, Concerta | Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder (ADHD), narcolepsy | |
| Mevidalen | LY3154207, Mevidalen hydroxybenzoate |
Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | |
| Mirtazapine | Remeron, esmirtazapine, Org 50081 |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | ||
| MK-8189 | Alzheimer's Disease (Phase 1) | Merck | Other Neurotransmitters | Small Molecule | ||
| Nabilone | Cesamet | Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Bausch Health Companies Inc. | Other Neurotransmitters | Small Molecule | Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries). |
| Nelotanserin | APD-125 | Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| Neramexane | MRZ 2/579 | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc., Merck | Other Neurotransmitters | Small Molecule | None |
| NS2330 | Tesofensine | Alzheimer's Disease (Discontinued) | NeuroSearch A/S | Other Neurotransmitters | Small Molecule | |
| Nuplazid | Pimavanserin, ACP-103, Pimavanserin tartrate |
Alzheimer's Disease (Rejected), Schizophrenia (Discontinued), Dementia (Rejected), Depression (Discontinued) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | Parkinson's psychosis |
| NYX-458 | PD-MCI (Discontinued) | Aptinyx Inc. | Other Neurotransmitters | Small Molecule | ||
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| PF-05212377 | PF-5212377, WYE-103760, SAM-760 |
Alzheimer's Disease (Discontinued) | Pfizer | Other Neurotransmitters | Small Molecule | |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Prazosin | Prazosin hydrochloride, Minipress, Hypovase, Vasoflex |
Alzheimer's Disease (Phase 4) | Other Neurotransmitters | Small Molecule | Hypertension | |
| PXT864 | PXT00864 | Alzheimer's Disease (Discontinued) | Pharnext | Other Neurotransmitters | Combination, Small Molecule | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rotigotine | Neupro | Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
| S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| S47445 | CX1632 | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc., Servier | Other Neurotransmitters | Small Molecule | |
| Safinamide | Xadago, Onstryv |
Multiple System Atrophy (Phase 2), Parkinson's Disease (Approved) | Newron, Zambon Company S.p.A. | Other Neurotransmitters | Small Molecule | |
| SAGE-718 | Dalzanemdor | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Huntington's Disease (Phase 2) | Sage Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | |
| SB 202026 | Memric | Alzheimer's Disease (Discontinued) | Other Neurotransmitters | Small Molecule | ||
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| SGS-742 | CGP-36742, DVD-742 |
Alzheimer's Disease (Discontinued) | Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| Suritozole | MD 26479 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| SUVN-G3031 | Samelisant, 17v |
Alzheimer's Disease (Phase 1) | Suven Life Sciences Ltd | Cholinergic System, Other Neurotransmitters | Small Molecule | |
| Trazodone | Trazodone hydrochloride, Oleptro, Desyrel |
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Other Neurotransmitters | Small Molecule | Depression | |
| Troriluzole | BHV-4157, trigriluzole, FC-4157 | Alzheimer's Disease (Discontinued) | Biohaven Pharmaceuticals | Other Neurotransmitters | Other | |
| UCB0022 | Parkinson's Disease (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | ||
| Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule | |
| Valproate | Depakote, Depakene, Valproic acid , Divalproex sodium |
Alzheimer's Disease (Inactive) | Abbott Laboratories | Other Neurotransmitters | Small Molecule | Epilepsy, Bipolar disorder, Migraine |
| VY-AADC | VY-AADC01, VY-AADC02 |
Parkinson's Disease (Discontinued) | Neurocrine Biosciences, Voyager Therapeutics | Other Neurotransmitters | DNA/RNA-based | |
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule |