Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AKST4290 | ALK4290, lazucirnon |
Parkinson's Disease (Phase 2) | Alkahest, Inc. | Inflammation | Small Molecule | |
| AL002 | Alzheimer's Disease (Phase 2) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
| AL003 | Alzheimer's Disease (Discontinued) | AbbVie, Alector | Inflammation | Immunotherapy (passive) | ||
| AL044 | Alzheimer's Disease (Phase 1) | Alector | Inflammation | Immunotherapy (passive) | ||
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Combination, Small Molecule | |
| ANX005 | Amyotrophic Lateral Sclerosis (Phase 2) | Annexon, Inc. | Inflammation, Other | Immunotherapy (passive) | ||
| Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| Baricitinib | Olumiant®, NCB28050, LY3009104 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) | Eli Lilly & Co. | Inflammation | Small Molecule | Rheumatoid arthritis, Eczema (Europe, Japan only) |
| Benfotiamine | S-benzoylthiamine-O-monophosphate, Vitamin B1, Thiamine |
Alzheimer's Disease (Phase 2) | Inflammation, Other | Supplement, Dietary | ||
| Bezisterim | NE3107, HE3286 |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) | BioVie Pharma | Inflammation, Other | Small Molecule | |
| BIIB094 | ION859, IONIS-BIIB7Rx |
Parkinson's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Inflammation, Other | DNA/RNA-based | |
| BIIB100 | KPT-350 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen | Inflammation, Other | Small Molecule | |
| Celecoxib | Celebrex | Alzheimer's Disease (Discontinued) | Pfizer | Inflammation | Small Molecule | Pain, Arthritis |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| Cocoa Flavanols | Mild Cognitive Impairment (Not Regulated) | Inflammation, Other | Supplement, Dietary | |||
| CpG 1018® | CpG oligodeoxynucleotides, CpG ODN |
Alzheimer's Disease (Phase 1) | Dynavax Technologies | Amyloid-Related, Inflammation | Immunotherapy (active), DNA/RNA-based | |
| CY6463 | IW-6463 | Alzheimer's Disease (Phase 2) | Cyclerion | Inflammation | Small Molecule | |
| DNL151 | BIIB122 | Parkinson's Disease (Phase 2) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | |
| DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
| DNL747 | SAR443060 | Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
| DNL788 | SAR443820, oditrasertib |
Amyotrophic Lateral Sclerosis (Discontinued) | Denali Therapeutics Inc., Sanofi | Inflammation | Small Molecule | |
| DNL919 | TAK-920, ATV:TREM2 |
Alzheimer's Disease (Discontinued) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Amyloid-Related, Inflammation | Immunotherapy (passive) | |
| Edicotinib | JNJ-40346527, JNJ-527, PRV-6527 |
Alzheimer's Disease (Phase 1) | Janssen | Inflammation | Small Molecule | |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| Etanercept | Enbrel™ | Alzheimer's Disease (Phase 2) | Amgen, Inc., Pfizer | Inflammation | Immunotherapy (passive) | Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis |
| Ezeprogind | AZP2006 , AZP-2006 |
Progressive Supranuclear Palsy (Phase 2) | AlzProtect | Tau, Inflammation, Other | Small Molecule | |
| Foralumab | TZLS-401, NI-0401, 28F11-AE |
Alzheimer's Disease (Phase 2) | Tiziana Life Sciences | Inflammation | Immunotherapy (passive) | |
| Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
| Gamunex | Intravenous Immunoglobulin, Human Albumin Combined With Flebogamma |
Alzheimer's Disease (Phase 2/3) | Grifols Biologicals Inc. | Amyloid-Related, Inflammation | Combination, Immunotherapy (passive) | Immunodeficiency, chronic inflammatory demyelinating neuropathy |
| GC021109 | Alzheimer's Disease (Phase 1) | GliaCure | Inflammation | Small Molecule | ||
| GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| GRF6021 | AKST/GRF6021 | Parkinson's Disease Dementia (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | |
| GV-971 | sodium oligomannate, sodium oligo-mannurarate |
Alzheimer's Disease (Inactive) | Shanghai Green Valley Pharmaceuticals | Amyloid-Related, Inflammation | Small Molecule | |
| HF0220 | Alzheimer's Disease (Discontinued) | Newron | Inflammation | Small Molecule | ||
| IBC-Ab002 | Alzheimer's Disease (Phase 1) | ImmunoBrain Checkpoint | Amyloid-Related, Inflammation, Other | Immunotherapy (passive) | ||
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Inzomelid | Emlenoflast, IZD174, MCC-7840 |
Alzheimer's Disease (Discontinued), Parkinson's Disease (Discontinued) | Hoffmann-La Roche, Inflazome Ltd. | Inflammation | Small Molecule | |
| Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
| Lomecel-B | mesenchymal stem cells | Alzheimer's Disease (Phase 2) | Longeveron | Inflammation, Other | Other | |
| Lornoxicam | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | JSW Lifesciences | Inflammation | Small Molecule | Pain in US | |
| Low Dose Interleukin-2 | COYA-301, Aldesleukin, Proleukin, COYA-302, ld IL-2 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) | Coya Therapeutics | Inflammation | Other | |
| Montelukast | Singulair, MK0476 | Alzheimer's Disease (Phase 2) | Intelgenx | Inflammation | Small Molecule | Asthma |
| MW150 | MW01-18-150SRM | Alzheimer's Disease (Phase 2) | Neurokine Therapeutics | Inflammation, Other | Small Molecule | |
| MW151 | MW01-2-151SRM, Minozac, MW01-2-151WH, compound 17 |
Alzheimer's Disease (Phase 1) | ImmunoChem Therapeutics, LLC | Inflammation | Small Molecule | |
| Naproxen | Aleve™, Anaprox™, Naprosyn™ |
Alzheimer's Disease (Discontinued) | Procter & Gamble | Inflammation | Small Molecule | Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness. |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) | CervoMed, Inc. | Inflammation | Small Molecule | |
| NPT520-34 | Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) | Neuropore Therapies, Inc. | alpha-synuclein, Inflammation, Other | Small Molecule | ||
| NT-0796 | Propan-2-yl (2R)-2-{[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)- carbamoyl]oxy}-3-(pyrimidin-2-yl)propanoate | Parkinson's Disease (Phase 1/2) | NodThera | Inflammation | Small Molecule | |
| NTRX-07 | MDA7 | Alzheimer's Disease (Phase 1) | NeuroTherapia, Inc. | Inflammation, Other | Small Molecule | |
| Octagam®10% | Intravenous Immunoglobulin, NewGam |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) | Octapharma | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency disorders |
| Pepinemab | VX15, VX15/2503 |
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) | Vaccinex, Inc. | Inflammation | Immunotherapy (passive) | |
| PhotoBioModulation | Low level light therapy, Low level laser therapy, Cold laser therapy, Transcranial infrared brain stimulation, Transcranial photobiomodulation, Transcranial near-infrared laser therapy (NILT), Transcranial low-level light therapy |
Alzheimer's Disease (Not Regulated), Mild Cognitive Impairment (Not Regulated), Parkinson's Disease (Not Regulated) | Inflammation, Unknown | Procedural Intervention | ||
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Prednisone | Alzheimer's Disease (Discontinued) | Inflammation | Small Molecule | |||
| Protollin | Alzheimer's Disease (Phase 1) | I-MAB Biopharma Co., Ltd., Jiangsu Nhwa Pharmaceutical Co., Ltd | Inflammation | Immunotherapy (active) | ||
| Rofecoxib | Vioxx™ | Alzheimer's Disease (Discontinued) | Merck | Inflammation | Small Molecule | Withdrawn from market |
| Sargramostim | GM-CSF Leukine , Leukine® |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Genzyme, Partner Therapeutics, Inc., Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
| Selnoflast | RO7486967, RG-6418, IZD-334, somalix |
Parkinson's Disease (Phase 1) | Hoffmann-La Roche, Inflazome Ltd. | Inflammation | Small Molecule | |
| Sensory Stimulation Systems | GENUS, Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Not Regulated), Down's Syndrome (Not Regulated) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| SNP318 | Alzheimer's Disease (Phase 1) | SciNeuro Pharmaceuticals | Inflammation | Small Molecule | ||
| TB006 | Alzheimer's Disease (Phase 1) | TrueBinding, Inc. | Inflammation | Immunotherapy (passive) | ||
| Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| TPN-101 | OBP-601, BMS-986001, censavudine, festinavir, 4'-ethynyl stavudine, 4'-ethynyl-d4T |
ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) | Transposon Therapeutics | Inflammation | Small Molecule, DNA/RNA-based | |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Discontinued) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Verdiperstat | AZD3241, BHV-3241 |
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) | AstraZeneca, Biohaven Pharmaceuticals | Inflammation, Other | Small Molecule | |
| VG-3927 | Alzheimer's Disease (Phase 1) | Vigil Neuroscience, Inc. | Amyloid-Related, Inflammation | Small Molecule | ||
| VGL101 | Iluzanebart | Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 2) | Vigil Neuroscience, Inc. | Inflammation, Other | Immunotherapy (passive) | |
| XPro1595 | Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345, XPro™ , LIVNate |
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) | INmune Bio Inc. | Inflammation | Other | |
| Young Plasma | Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other |