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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAV-GAD AAV-GAD2,
NLX-P101
Parkinson's Disease (Phase 1/2) MeiraGTx Limited Other Neurotransmitters DNA/RNA-based
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
ACP-204 Alzheimer's Disease (Phase 2/3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
ALX-001 BMS-984923 Alzheimer's Disease (Phase 1) Allyx Therapeutics, Inc. Amyloid-Related, Other Neurotransmitters Small Molecule
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
AVP-786 Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AVP-923 Nuedexta,
Zenvia
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AXS-05 Dextromethorphan/bupropion,
Auvelity
Alzheimer's Disease (Phase 2/3) Axsome Therapeutics, Inc. Other Neurotransmitters Combination, Small Molecule Major depressive disorder
Bemdaneprocel BRT-DA01,
MSK-DA01
Parkinson's Disease (Phase 1) Bayer, BlueRock Therapeutics Other Neurotransmitters, Other Other
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
BI 409306 SUB 166499 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Approved), Schizophrenia (Approved) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Cannabidiol CBD,
Epidiolex
Alzheimer's Disease (Phase 2) Other Neurotransmitters Small Molecule Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex
Citalopram escitalopram,
Celexa,
Lexapro ,
Cipralex
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) Other Neurotransmitters Small Molecule Depression, generalized anxiety disorder
CST-103 Clenbuterol Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) Other Neurotransmitters Small Molecule Asthma, in countries outside the U.S.
CST-2032 Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) CuraSen Therapeutics, Inc. Other Neurotransmitters Small Molecule
CVN424 Parkinson's Disease (Phase 2) Cerevance Other Neurotransmitters Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
Dipraglurant ADX48621 Parkinson's Disease (Discontinued) Addex Therapeutics Other Neurotransmitters Small Molecule
Dronabinol THC ,
Marinol,
Syndros,
delta-9-tetrahydrocannabinol,
delta-9-THC
Alzheimer's Disease (Phase 2) AbbVie, Others Other Neurotransmitters Small Molecule Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
Guanfacine Intuniv,
SPD503,
Afken,
Estulic,
Tenex
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder, hypertension
Iclepertin BI 425809 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 3) Boehringer Ingelheim Other Neurotransmitters Small Molecule
Idalopirdine Lu AE58054,
SGS 518
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Kynmobi APL-130277,
apomorphine hydrochloride sublingual thin film
Parkinson's Disease (Approved) Sunovion Pharmaceuticals Inc. Other Neurotransmitters Small Molecule
Levodopa L-Dopa, Sinemet,
Duodopa, Duopa,
Inbrija,
Parcopa,
Prolopa,
Rytary,
Stalevo,
Foslevodopa
Parkinson's Disease (Approved) AbbVie, Acorda Therapeutics, Inc., Amneal Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
Lumateperone ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 3) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Alzheimer's Disease (Approved) Forest Laboratories, Inc., Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
Methylphenidate Ritalin, Concerta Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder (ADHD), narcolepsy
Mevidalen LY3154207,
Mevidalen hydroxybenzoate
Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) Eli Lilly & Co. Other Neurotransmitters Small Molecule
Mirtazapine Remeron,
esmirtazapine,
Org 50081
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule
MK-8189 Alzheimer's Disease (Phase 1) Merck Other Neurotransmitters Small Molecule
Nabilone Cesamet Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) Bausch Health Companies Inc. Other Neurotransmitters Small Molecule Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries).
Nelotanserin APD-125 Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
Nuplazid Pimavanserin,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Rejected), Schizophrenia (Discontinued), Dementia (Rejected), Depression (Discontinued) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
NYX-458 PD-MCI (Discontinued) Aptinyx Inc. Other Neurotransmitters Small Molecule
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Alzheimer's Disease (Discontinued) Pfizer Other Neurotransmitters Small Molecule
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Hypertension
PXT864 PXT00864 Alzheimer's Disease (Discontinued) Pharnext Other Neurotransmitters Combination, Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rotigotine Neupro Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
S47445 CX1632 Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule
Safinamide Xadago,
Onstryv
Multiple System Atrophy (Phase 2), Parkinson's Disease (Approved) Newron, Zambon Company S.p.A. Other Neurotransmitters Small Molecule
SAGE-718 Dalzanemdor Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Huntington's Disease (Phase 2) Sage Therapeutics, Inc. Other Neurotransmitters Small Molecule
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG Other Neurotransmitters, Other Small Molecule
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
SUVN-G3031 Samelisant,
17v
Alzheimer's Disease (Phase 1) Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule
Trazodone Trazodone hydrochloride,
Oleptro,
Desyrel
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) Other Neurotransmitters Small Molecule Depression
Troriluzole BHV-4157, trigriluzole, FC-4157 Alzheimer's Disease (Discontinued) Biohaven Pharmaceuticals Other Neurotransmitters Other
UCB0022 Parkinson's Disease (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Alzheimer's Disease (Inactive) Abbott Laboratories Other Neurotransmitters Small Molecule Epilepsy, Bipolar disorder, Migraine
VY-AADC VY-AADC01,
VY-AADC02
Parkinson's Disease (Discontinued) Neurocrine Biosciences, Voyager Therapeutics Other Neurotransmitters DNA/RNA-based
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule