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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAB-003 PF-05236812 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Affitope AD02 Alzheimer's Disease (Discontinued) AFFiRiS AG Amyloid-Related Immunotherapy (active)
Alzhemed™ Vivimind™,
Tramiprosate,
NC-531,
homotaurine,
3-APS
Alzheimer's Disease (Discontinued) Neurochem, Inc. Amyloid-Related Supplement, Dietary None
AN-1792 AIP 001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (active) None
Atabecestat JNJ-54861911 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Discontinued) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
Crenezumab MABT5102A ,
RG7412
Alzheimer's Disease (Discontinued) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
DNL919 TAK-920,
ATV:TREM2
Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company Amyloid-Related, Inflammation Immunotherapy (passive)
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
EVP-0962 EVP 0015962 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gantenerumab RO4909832,
RG1450,
R1450
Alzheimer's Disease (Discontinued) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Lanabecestat AZD3293 ,
LY3314814,
BACE inhibitor
Alzheimer's Disease (Discontinued) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Lu AF20513 Alzheimer's Disease (Discontinued) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Amyloid-Related Immunotherapy (active)
LY2599666 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3202626 BACE Inhibitor Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
PF-06648671 Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06751979 BACE inhibitor Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Pfizer Amyloid-Related Immunotherapy (passive) None
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
SAR228810 Alzheimer's Disease (Discontinued) Sanofi Amyloid-Related Immunotherapy (passive)
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Solanezumab LY2062430 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
Thalidomide Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
Umibecestat CNP520,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
Vanutide cridificar ACC-001,
PF-05236806
Alzheimer's Disease (Discontinued) Janssen Amyloid-Related Immunotherapy (active) None
Varoglutamstat PQ912 Alzheimer's Disease (Discontinued) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Merck Amyloid-Related Small Molecule