Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
| Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
| Baricitinib | Olumiant®, NCB28050, LY3009104 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) | Eli Lilly & Co. | Inflammation | Small Molecule | Rheumatoid arthritis, Eczema (Europe, Japan only) |
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
| Cannabidiol | CBD, Epidiolex |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex | |
| Ceperognastat | LY3372689 | Alzheimer's Disease (Phase 2) | Eli Lilly & Co. | Tau | Small Molecule | |
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| CST-103 | Clenbuterol | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) | Other Neurotransmitters | Small Molecule | Asthma, in countries outside the U.S. | |
| CST-2032 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) | CuraSen Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | ||
| CT1812 | Elayta | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| CY6463 | IW-6463 | Alzheimer's Disease (Phase 2) | Cyclerion | Inflammation | Small Molecule | |
| Dayvigo | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
| Deferiprone | Ferriprox | Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Apotex Inc., Chiesi Pharmaceuticals Inc. | Metals | Small Molecule | Iron overload due to thalassemia syndromes |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Dronabinol | THC , Marinol, Syndros, delta-9-tetrahydrocannabinol, delta-9-THC |
Alzheimer's Disease (Phase 2) | AbbVie, Others | Other Neurotransmitters | Small Molecule | Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy |
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
| Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
| Montelukast | Singulair, MK0476 | Alzheimer's Disease (Phase 2) | Intelgenx | Inflammation | Small Molecule | Asthma |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| MW150 | MW01-18-150SRM | Alzheimer's Disease (Phase 2) | Neurokine Therapeutics | Inflammation, Other | Small Molecule | |
| NA-831 | Traneurocin | Alzheimer's Disease (Phase 2) | Biomed Industries, NeuroActiva™ Inc. | Cholinergic System | Small Molecule | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) | CervoMed, Inc. | Inflammation | Small Molecule | |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| Obicetrapib | TA-8995 | Alzheimer's Disease (Phase 2) | NewAmsterdam Pharma | Cholesterol | Small Molecule | |
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| PU-AD | PU-HZ151, icapamespib |
Alzheimer's Disease (Phase 2) | Samus Therapeutics | Other | Small Molecule | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Relyvrio | Albrioza, AMX0035 |
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ALS |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rotigotine | Neupro | Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
| SAGE-718 | Dalzanemdor | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Huntington's Disease (Phase 2) | Sage Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| TW001 | FNP122, FAB122, oral edaravone |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) | Treeway B.V. | Other | Small Molecule | |
| Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule | |
| Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
| Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule |