Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
| Atomoxetine | ATX, Strattera |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Eli Lilly & Co. | Other Neurotransmitters | Small Molecule | ADHD in US |
| Cannabidiol | CBD, Epidiolex |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters | Small Molecule | Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex | |
| CST-103 | Clenbuterol | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) | Other Neurotransmitters | Small Molecule | Asthma, in countries outside the U.S. | |
| CST-2032 | Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) | CuraSen Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | ||
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Dronabinol | THC , Marinol, Syndros, delta-9-tetrahydrocannabinol, delta-9-THC |
Alzheimer's Disease (Phase 2) | AbbVie, Others | Other Neurotransmitters | Small Molecule | Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy |
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rotigotine | Neupro | Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
| SAGE-718 | Dalzanemdor | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Huntington's Disease (Phase 2) | Sage Therapeutics, Inc. | Other Neurotransmitters | Small Molecule | |
| Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule |