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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AL101 GSK-4527226 Alzheimer's Disease (Phase 2) Alector, GlaxoSmithKline (GSK) Other Immunotherapy (passive)
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
Benfotiamine S-benzoylthiamine-O-monophosphate,
Vitamin B1,
Thiamine
Alzheimer's Disease (Phase 2) Inflammation, Other Supplement, Dietary
Bifidobacterium breve A1 MCC1274,
B. breve
Mild Cognitive Impairment (Phase 2) Morinaga Milk Industry Co., Ltd Other Supplement, Dietary
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Bryostatin 1 Alzheimer's Disease (Phase 2) Synaptogenix, Inc. Other Other
Candesartan Atacand,
Candesartan cilexetil
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) AstraZeneca, Takeda Pharmaceutical Company Other Small Molecule Hypertension, congestive heart failure
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Supplement, Dietary None
Dayvigo Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
Deep Brain Stimulation-nucleus basalis of Meynert DBS-nbM Alzheimer's Disease (Phase 2) Cholinergic System, Other Procedural Intervention
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
Leuprolide Leuprolide acetate ,
Lupron Depot,
Eligard
Alzheimer's Disease (Phase 2) Tolmar Pharmaceuticals, Inc. Other Other Advanced prostate cancer
Levetiracetam Keppra Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Liraglutide Victoza™,
Saxenda™
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Diabetes, weight loss
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Lomecel-B mesenchymal stem cells Alzheimer's Disease (Phase 2) Longeveron Inflammation, Other Other
Losartan Cozaar®,
MK0954
Alzheimer's Disease (Phase 2) Merck Other Small Molecule Hypertension, diabetic neuropathy
Melatonin Alzheimer's Disease (Phase 2) Other Supplement, Dietary None
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin,
glulisine
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
PU-AD PU-HZ151,
icapamespib
Alzheimer's Disease (Phase 2) Samus Therapeutics Other Small Molecule
Relyvrio Albrioza,
AMX0035
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule ALS
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Sargramostim GM-CSF Leukine ,
Leukine®
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Genzyme, Partner Therapeutics, Inc., Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Seltorexant JNJ-42847922,
MIN-202
Alzheimer's Disease (Phase 2) Janssen Other Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
TW001 FNP122,
FAB122,
oral edaravone
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) Treeway B.V. Other Small Molecule
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule