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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ALN-APP Alzheimer's Disease (Phase 1) Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. Amyloid-Related DNA/RNA-based
ALX-001 BMS-984923 Alzheimer's Disease (Phase 1) Allyx Therapeutics, Inc. Amyloid-Related, Other Neurotransmitters Small Molecule
ALZ-101 Alzheimer's Disease (Phase 1) Alzinova AB Amyloid-Related Immunotherapy (active)
AV-1959D AV-1959 Alzheimer's Disease (Phase 1) Amyloid-Related Immunotherapy (active)
CpG 1018® CpG oligodeoxynucleotides,
CpG ODN
Alzheimer's Disease (Phase 1) Dynavax Technologies Amyloid-Related, Inflammation Immunotherapy (active), DNA/RNA-based
CS6253 Cogpep™,
CS-6253
Alzheimer's Disease (Phase 1) Artery Therapeutics, Inc. Amyloid-Related, Cholesterol Small Molecule
Efavirenz Efavirenz Alzheimer's Disease (Phase 1) Amyloid-Related, Tau, Cholesterol Small Molecule HIV infection
Focused Ultrasound – Blood-Brain Barrier FUS-BBB,
MRgFUS,
MRI-Guided Focused Ultrasound,
FUS+MB
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) Amyloid-Related, Other Procedural Intervention
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
LX1001 AAVrh.10-APOE2,
AAVrh.10hAPOE2
Alzheimer's Disease (Phase 1) Lexeo Therapeutics Amyloid-Related DNA/RNA-based
MEDI1814 Alzheimer's Disease (Phase 1) AstraZeneca, Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
MemorEM Transcranial Electromagnetic Treatment TEMT Alzheimer's Disease (Phase 1) NeuroEM Therapeutics, Inc. Amyloid-Related, Other Procedural Intervention
PMN310 Alzheimer's Disease (Phase 1) ProMIS Neurosciences, Inc. Amyloid-Related Immunotherapy (passive)
PRI-002 Contraloid,
contraloid acetate,
RD2
Alzheimer's Disease (Phase 1) Priavoid GmbH Amyloid-Related Small Molecule
PRX012 Alzheimer's Disease (Phase 1) Prothena Amyloid-Related Immunotherapy (passive)
VG-3927 Alzheimer's Disease (Phase 1) Vigil Neuroscience, Inc. Amyloid-Related, Inflammation Small Molecule