Therapeutics

Sabeluzole

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Overview

Name: Sabeluzole
Synonyms: R58735
Therapy Type: Small Molecule (timeline)
Target Type: Unknown
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Inactive)

Background

Sabeluzole has been reported to reduce glutatmate toxicity in part by reducing NMDA-induced inward current (Van der Valk et al., 1993). It also has been shown to affect cytoskeletal stability (Geerts et al., 1996) and tau expression (Uberti et al., 1997). 

Last Updated: 09 Jan 2014

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References

Paper Citations

  1. Van der Valk JB, Vijverberg HP. Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current. Eur J Pharmacol. 1993 Feb 23;232(1):131-4. PubMed.
  2. Geerts H, Nuydens R, De Jong M, Cornelissen F, Nuyens R, Wouters L. Sabeluzole stabilizes the neuronal cytoskeleton. Neurobiol Aging. 1996 Jul-Aug;17(4):573-81. PubMed.
  3. Uberti D, Rizzini C, Galli P, Pizzi M, Grilli M, Lesage A, Spano P, Memo M. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103. PubMed.

Further Reading

No Available Further Reading