Species: Mouse
Genes: Trem2
Modification: Trem2: Knock-In
Disease Relevance: Alzheimer's Disease, Frontotemporal Dementia, Nasu-Hakola Disease
Strain Name: B6(C3)-Trem2^{tm1c(EUCOMM)Wtsi}/AdiujJ
Genetic Background: B6(C3)
Availability: The Jackson Lab: Stock# 029853; Live

Summary

These mice possess a floxed Trem2 allele. When bred to mice expressing Cre-recombinase driven by specific promoters, offspring can be used to study the conditional knockout of Trem2.

Heterozygotes are viable and fertile; viability and fertility in homozygous mice have not yet been reported.

Modification Details

Targeted insertion of LoxP sites flanking exons 2 and 3 of the mouse Trem2 gene.

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References

External Citations

1. The Jackson Lab: Stock# 029853

Further Reading

No Available Further Reading