1. 1 Models
2. 0 Visualizations

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• Name
• Other Names
• Strain Name
• Genetic Background
• Gene
• Mutation
• Modification Info
• Modification
• Disease
• Neuropathology
• Behavior/Cognition
• Other Phenotype
• Availability
• Primary Paper
• Visualization

	Name	Other Names	Strain Name	Genetic Background	Gene	Mutation	Modification Info	Modification	Disease	Neuropathology	Behavior/Cognition	Other Phenotype	Availability	Primary Paper	Visualization
Mouse Models (1)
	PSEN1-YAC (line G9)	line G9, H163R mutant PS-1 YAC, B6-G9, PS1-YAC	B6.129S4-Tg(PSEN1H163R)G9Btla/J	Origin: 129S4/SvJae, backcrossed to C57BL/6	PSEN1	PSEN1 H163R	A 1000 kb YAC transgene (788H12) containing the entire human PSEN1 gene with the H163R mutation. Transgene also has ~550 kb of upstream and 350 kb of downstream flanking sequences.	PSEN1: Transgenic	Alzheimer's Disease	Elevated Aβ42 in the brain and plasma. Higher levels and earlier Aβ deposition when crossed with APP YAC line R1.40.	Unknown.	Alternatively spliced human PSEN1 transcripts.	The Jackson Lab: Stock# 006469; Cryopreserved	Lamb et al., 1999	No