Research Models Search Results Compare | ALZFORUM

1 Models
1 Visualizations

Mouse Models (1)
	Name	Other Names	Strain Name	Genetic Background	Gene	Mutation	Modification Info	Modification	Disease	Neuropathology	Behavior/Cognition	Other Phenotype	Availability	Primary Paper	Visualization
	A7 APP transgenic			C57BL/6J	APP	APP K670_M671delinsNL (Swedish), APP T714I (Austrian)	Transgene-expressing mutant APP with the Swedish mutation (K670N/M671L) and the Austrian mutation (T714I) under the control of the Thy1.2 promoter.	APP: Transgenic	Alzheimer's Disease	Progressive amyloid deposition in the cerebral cortex by approximately 9-12 months.	Unknown.	Optogenetic stimulation induced epileptic seizures.	Unknown	Yamada et al., 2009	Yes

AD-related Research Models

When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

A7 APP transgenic

Observed

X
Plaques at 39

These mice develop progressive amyloid deposition in the cerebral cortex by 9-12 months. By 21 months of age amyloid pathology is extensive.

Absent

No Data

Genes	Mutations	Modification	Disease	Neuropathology	Behavior/Cognition
APP	APP K670_M671delinsNL (Swedish), APP T714I (Austrian)	APP: Transgenic	Alzheimer's Disease	Progressive amyloid deposition in the cerebral cortex by approximately 9-12 months.	Unknown.

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