Research Models
Selected Results
1 Models
Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
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Mouse Models (1)
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B6.Cg-Tg(Thy1-APP)3Somm/J; Psen1tm1.1Tcs | C57BL/6J | APP, PSEN1 | PSEN1 R278I | This is a cross between APP23 mice, which overexpress APP751 with the Swedish mutation driven by the murine Thy1 promoter, and PSEN1 knock-in mice expressing human PSEN1 with the R278I mutation under the endogenous promoter. | APP: Transgenic; PSEN1: Knock-In | Alzheimer's Disease | Amyloid deposition by 6 months of age in the cortex and hippocampus. Abundant reactive astrocytes in the vicinity of plaques. Elevated Aβ43 in the brain by 3 months. High density of cored plaques. Pyroglutamate Aβ (N3pE-Aβ) associated with amyloid plaques. | Short-term memory deficits apparent by 3-4 months as measured by the Y maze. | Reduced γ-secretase activity. | Available through Takaomi Saido | Saito et al., 2011 | Yes |
1 Visualizations
AD-related Research Models
Phenotypes Examined
- Plaques
- Tangles
- Neuronal Loss
- Gliosis
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.
APP23 x PS1-R278I
Observed
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Plaques at 26
By 6 months of age amyloid plaques accumulate in the cortex and hippocampus. A high percentage of plaques are thioflavin-S –positive cored plaques.
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Gliosis at 39
Astrocytosis in the vicinity of plaques in the hippocampus and cortex by 9 months.
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Cognitive Impairment at 13
Short-term memory deficits are apparent by 3 to 4 months as measured by the Y maze.
Absent
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Tangles at
Not observed.
No Data
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Neuronal Loss at
No data.
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Synaptic Loss at
No data.
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Changes in LTP/LTD at
No data.
Genes | Mutations | Modification | Disease | Neuropathology | Behavior/Cognition |
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APP, PSEN1 | PSEN1 R278I | APP: Transgenic; PSEN1: Knock-In | Alzheimer's Disease | Amyloid deposition by 6 months of age in the cortex and hippocampus. Abundant reactive astrocytes in the vicinity of plaques. Elevated Aβ43 in the brain by 3 months. High density of cored plaques. Pyroglutamate Aβ (N3pE-Aβ) associated with amyloid plaques. |
Short-term memory deficits apparent by 3-4 months as measured by the Y maze. |