Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
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Mouse Models (1)
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| B6CBA-Tg(Thy1.2-hAPParc) | C57BL/6-CBA | APP | APP E693G (Arctic) | Transgenic mice with human APP (isoform 695) bearing the Arctic APP mutation (E693G). | APP: Transgenic | Alzheimer's Disease | Mild amyloid pathology with a relatively late onset, starting with intracellular Aβ, then diffuse extracellular Aβ deposits in the subiculum, expanding to interconnected brain regions such as retrosplenial granular cortex, thalamus, and mammillary bodies. Pathology more severe in females. | Spatial learning and memory deficit in the Barnes maze test in heterozygous females mice at 15 months. | Available through Annica Rönnbäck | Rönnbäck et al., 2011 | No | ||||