Research Models Search Results Compare | ALZFORUM

1 Models
1 Visualizations

Rat Models (1)
	Name	Other Names	Strain Name	Genetic Background	Gene	Mutation	Modification Info	Modification	Disease	Neuropathology	Behavior/Cognition	Other Phenotype	Availability	Primary Paper	Visualization
	App knock‐in (Icelandic mutation and humanized Aβ)	<p>-</p>, <p>App<sup>p</sup></p>		Long-Evans	App	APP A673T (Icelandic)	Four point mutations were introduced into the rat App gene to humanize the Aβ sequence (G5R, F10Y, and R13H of Aβ) and to add the Icelandic mutation A673T (numbered as in the 770-amino-acid isoform of human APP).	App: Knock-In	Alzheimer's Disease	Unknown.	Unknown.		Available through Luciano D'Adamio.	Tambini et al., 2020	Yes

AD-related Research Models

When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

App knock‐in (Icelandic mutation and humanized Aβ)

Observed

Absent

No Data

Genes	Mutations	Modification	Disease	Neuropathology	Behavior/Cognition
App	APP A673T (Icelandic)	App: Knock-In	Alzheimer's Disease	Unknown.	Unknown.

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