Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Rat Models (1)
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| <p>-</p>, <p>App<sup>p</sup></p> | Long-Evans | App | APP A673T (Icelandic) | Four point mutations were introduced into the rat App gene to humanize the Aβ sequence (G5R, F10Y, and R13H of Aβ) and to add the Icelandic mutation A673T (numbered as in the 770-amino-acid isoform of human APP). | App: Knock-In | Alzheimer's Disease | Unknown. | Unknown. | Available through Luciano D'Adamio. | Tambini et al., 2020 | Yes | ||||
1 Visualizations
AD-related Research Models
Phenotypes Examined
- Plaques
- Tangles
- Neuronal Loss
- Gliosis
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.
App knock‐in (Icelandic mutation and humanized Aβ)
Observed
Absent
No Data
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Plaques at
No data.
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Tangles at
No data.
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Neuronal Loss at
No data.
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Gliosis at
No data.
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Synaptic Loss at
No data.
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Changes in LTP/LTD at
No data.
-
Cognitive Impairment at
No data.
| Genes | Mutations | Modification | Disease | Neuropathology | Behavior/Cognition |
|---|---|---|---|---|---|
| App | APP A673T (Icelandic) | App: Knock-In | Alzheimer's Disease | Unknown. |
Unknown. |