Guerreiro RJ, Lohmann E, Brás JM, Gibbs JR, Rohrer JD, Gurunlian N, Dursun B, Bilgic B, Hanagasi H, Gurvit H, Emre M, Singleton A, Hardy J. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol. 2013 Jan;70(1):78-84. PubMed.

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This paper appears in the following:

News

  1. Mutations in TREM2 Cause Frontotemporal Dementia
  2. Does Progranulin Play Both Sides in AD and FTD?

Mutations

  1. TREM2 T66M
  2. TREM2 Q33Ter
  3. TREM2 Y38C
  4. TREM2 D86V

Research Models

  1. Trem2 T66M KI
  2. Trem2 KO (JAX)
  3. Trem2 Y38C KI
  4. Trem2 KO (KOMP)
  5. Trem2 KO (KOMP) x htau
  6. Trem2 KO (Colonna)
  7. Trem2 KO (Colonna) x 5XFAD
  8. Trem2 KO (Colonna) x PS19

Research Timeline Event

  1. TREM2 mutations found in FTD, AD