Thornton P, Sevalle J, Deery MJ, Fraser G, Zhou Y, Ståhl S, Franssen EH, Dodd RB, Qamar S, Gomez Perez-Nievas B, Nicol LS, Eketjäll S, Revell J, Jones C, Billinton A, St George-Hyslop PH, Chessell I, Crowther DC. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. EMBO Mol Med. 2017 Oct;9(10):1366-1378. PubMed.

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This paper appears in the following:

News

  1. TREM2 Cleavage Site Pinpointed: A Gateway to New Therapies?

Mutations

  1. TREM2 H157Y

Research Models

  1. Trem2-H157Y knock-in
  2. TREM2-sol
  3. TREM2-IPD
  4. Trem2-IPDxAPP23xPS45
  5. Trem2-H157Y x 5xFAD